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- W2050251015 abstract "The central glucagon-like peptide (GLP)-1 receptor mediates a number of metabolic processes, including feeding, body weight and glucose homeostasis. More recently, roles in energy expenditure and reward pathway modulation have been described. GLP-1 receptor agonism promotes insulin release and is currently used to treat type 2 diabetes humans, with a common side effect being weight loss. It is likely that many of these metabolic effects are mediated by GLP-1Rs located in the central nervous system, throughout areas known to be important in control of energy homeostasis. The physiological role of the GLP-1 receptor signalling in each of these brain nuclei is becoming clearer and the GLP-1 system appears to act as an integrator of peripheral energy availability and effector of metabolic regulation. This makes it an attractive target for obesity therapies, with excellent pre-clinical efficacy seen in molecules combining GLP-1 receptor agonism with glucagon receptor agonism. This review discusses what is known about the functions of the GLP-1 receptor in the central nervous system, and highlights the ways that this system may be targeted for development of new obesity therapeutics." @default.
- W2050251015 created "2016-06-24" @default.
- W2050251015 creator A5081887908 @default.
- W2050251015 date "2013-06-14" @default.
- W2050251015 modified "2023-09-26" @default.
- W2050251015 title "Glucagon-Like Peptide-1 Receptor in the Brain: Role in Neuroendocrine Control of Energy Metabolism and Treatment Target for Obesity" @default.
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- W2050251015 cites W1964504958 @default.
- W2050251015 cites W1966059930 @default.
- W2050251015 cites W1967858101 @default.
- W2050251015 cites W1969921050 @default.
- W2050251015 cites W1980088741 @default.
- W2050251015 cites W1989616977 @default.
- W2050251015 cites W1992020371 @default.
- W2050251015 cites W1992221965 @default.
- W2050251015 cites W1997594107 @default.
- W2050251015 cites W1997970568 @default.
- W2050251015 cites W1998882505 @default.
- W2050251015 cites W2000428521 @default.
- W2050251015 cites W2008899423 @default.
- W2050251015 cites W2010340764 @default.
- W2050251015 cites W2013082477 @default.
- W2050251015 cites W2017101080 @default.
- W2050251015 cites W2018532926 @default.
- W2050251015 cites W2021128495 @default.
- W2050251015 cites W2024752909 @default.
- W2050251015 cites W2024958149 @default.
- W2050251015 cites W2033945483 @default.
- W2050251015 cites W2036736965 @default.
- W2050251015 cites W2048006862 @default.
- W2050251015 cites W2048809940 @default.
- W2050251015 cites W2058058762 @default.
- W2050251015 cites W2058514432 @default.
- W2050251015 cites W2068226015 @default.
- W2050251015 cites W2069884626 @default.
- W2050251015 cites W2076744704 @default.
- W2050251015 cites W2077496630 @default.
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- W2050251015 cites W2104763836 @default.
- W2050251015 cites W2105128757 @default.
- W2050251015 cites W2111741353 @default.
- W2050251015 cites W2114699589 @default.
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- W2050251015 cites W2143534172 @default.
- W2050251015 cites W2144166875 @default.
- W2050251015 cites W2144288812 @default.
- W2050251015 cites W2144589456 @default.
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- W2050251015 cites W2170256989 @default.
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- W2050251015 cites W2248388289 @default.
- W2050251015 cites W4234825176 @default.
- W2050251015 cites W4248492965 @default.
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- W2050251015 doi "https://doi.org/10.1111/jne.12039" @default.
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