FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050253095> ?p ?o ?g. }

• W2050253095 endingPage "142" @default.
• W2050253095 startingPage "132" @default.
• W2050253095 abstract "Bone marrow-derived mononuclear cell (BMMC) treatment in acute myocardial infarction (AMI) has been shown to have a beneficial effect. Our objective was to study in detail the histopathological process after the cell therapy after intramyocardial (IM) or intracoronary (IC) administration of BMMCs following experimental AMI. Twenty-fours pigs were randomized to the IM group (n=8), the IC group (n=8), and the control group (n=8).After 90 min of transient occlusion of the circumflex coronary artery, BMMCs were injected either intramyocardially or by a transfemoral catheter into the circumflex coronary artery. Echocardiography was performed preoperatively, postoperatively, and after a 21-day recovery period. The heart biopsies were examined histopathologically. Volumetric ex vivo CT scan was performed to evaluate calcification of the infarcted myocardium. The ejection fraction (EF) showed significant recovery in the IM group compared to the control group at Day 21 (P=.05). Despite beneficial histological changes in the infarction site in the IC group, compared to the control group, EF failed to recover. Reduction of collagen density that depicts scar formation was seen in both cell therapy groups compared to the control (P<.001). The number of mitotic cells was higher in the control group compared to the cell therapy groups (P<.001). The IC and IM groups differed significantly from each other in muscle-specific actin staining (P<.001) and smooth muscle actin staining (P<.004). The IM therapy group showed higher density for both stainings. Additionally, macrophage density was higher in the IC group compared to the IM and control groups (P<.002). Both cell therapy regimens substantially diminished tissue calcification; due to the large variation, the effect was not statistically significant. BMMC therapy launches cellular changes that affect mostly the repair process in the granulation tissue. The cell transplantation method might have some effect on the magnitude of the effect." @default.
• W2050253095 created "2016-06-24" @default.
• W2050253095 creator A5012644605 @default.
• W2050253095 creator A5031785884 @default.
• W2050253095 creator A5038218695 @default.
• W2050253095 creator A5049271390 @default.
• W2050253095 creator A5049594255 @default.
• W2050253095 creator A5052668307 @default.
• W2050253095 creator A5060570812 @default.
• W2050253095 creator A5061787166 @default.
• W2050253095 creator A5071961569 @default.
• W2050253095 creator A5077814457 @default.
• W2050253095 creator A5079377649 @default.
• W2050253095 creator A5080965346 @default.
• W2050253095 date "2012-05-01" @default.
• W2050253095 modified "2023-09-27" @default.
• W2050253095 title "Granulation tissue is altered after intramyocardial and intracoronary bone marrow-derived cell transfer for experimental acute myocardial infarction" @default.
• W2050253095 cites W1970761946 @default.
• W2050253095 cites W1982426523 @default.
• W2050253095 cites W1986046059 @default.
• W2050253095 cites W1990163699 @default.
• W2050253095 cites W1996215631 @default.
• W2050253095 cites W1999131060 @default.
• W2050253095 cites W2009184449 @default.
• W2050253095 cites W2023417206 @default.
• W2050253095 cites W2034452944 @default.
• W2050253095 cites W2048989520 @default.
• W2050253095 cites W2060178686 @default.
• W2050253095 cites W2061050734 @default.
• W2050253095 cites W2074505815 @default.
• W2050253095 cites W2074906795 @default.
• W2050253095 cites W2075344844 @default.
• W2050253095 cites W2084693500 @default.
• W2050253095 cites W2091475869 @default.
• W2050253095 cites W2097834438 @default.
• W2050253095 cites W2103969395 @default.
• W2050253095 cites W2105840074 @default.
• W2050253095 cites W2109916380 @default.
• W2050253095 cites W2119583980 @default.
• W2050253095 cites W2125155374 @default.
• W2050253095 cites W2131388270 @default.
• W2050253095 cites W2131753550 @default.
• W2050253095 cites W2134996862 @default.
• W2050253095 cites W2137891306 @default.
• W2050253095 cites W2140928988 @default.
• W2050253095 cites W2151722542 @default.
• W2050253095 cites W2154088932 @default.
• W2050253095 cites W2159002269 @default.
• W2050253095 cites W2159999899 @default.
• W2050253095 cites W2164506013 @default.
• W2050253095 doi "https://doi.org/10.1016/j.carpath.2011.06.002" @default.
• W2050253095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21839651" @default.
• W2050253095 hasPublicationYear "2012" @default.
• W2050253095 type Work @default.
• W2050253095 sameAs 2050253095 @default.
• W2050253095 citedByCount "2" @default.
• W2050253095 countsByYear W20502530952014 @default.
• W2050253095 countsByYear W20502530952015 @default.
• W2050253095 crossrefType "journal-article" @default.
• W2050253095 hasAuthorship W2050253095A5012644605 @default.
• W2050253095 hasAuthorship W2050253095A5031785884 @default.
• W2050253095 hasAuthorship W2050253095A5038218695 @default.
• W2050253095 hasAuthorship W2050253095A5049271390 @default.
• W2050253095 hasAuthorship W2050253095A5049594255 @default.
• W2050253095 hasAuthorship W2050253095A5052668307 @default.
• W2050253095 hasAuthorship W2050253095A5060570812 @default.
• W2050253095 hasAuthorship W2050253095A5061787166 @default.
• W2050253095 hasAuthorship W2050253095A5071961569 @default.
• W2050253095 hasAuthorship W2050253095A5077814457 @default.
• W2050253095 hasAuthorship W2050253095A5079377649 @default.
• W2050253095 hasAuthorship W2050253095A5080965346 @default.
• W2050253095 hasConcept C10882517 @default.
• W2050253095 hasConcept C126322002 @default.
• W2050253095 hasConcept C142724271 @default.
• W2050253095 hasConcept C1491633281 @default.
• W2050253095 hasConcept C164705383 @default.
• W2050253095 hasConcept C197321550 @default.
• W2050253095 hasConcept C2776820930 @default.
• W2050253095 hasConcept C2777798775 @default.
• W2050253095 hasConcept C2778198053 @default.
• W2050253095 hasConcept C2778742706 @default.
• W2050253095 hasConcept C2780007613 @default.
• W2050253095 hasConcept C500558357 @default.
• W2050253095 hasConcept C54355233 @default.
• W2050253095 hasConcept C71924100 @default.
• W2050253095 hasConcept C78085059 @default.
• W2050253095 hasConcept C86803240 @default.
• W2050253095 hasConceptScore W2050253095C10882517 @default.
• W2050253095 hasConceptScore W2050253095C126322002 @default.
• W2050253095 hasConceptScore W2050253095C142724271 @default.
• W2050253095 hasConceptScore W2050253095C1491633281 @default.
• W2050253095 hasConceptScore W2050253095C164705383 @default.
• W2050253095 hasConceptScore W2050253095C197321550 @default.
• W2050253095 hasConceptScore W2050253095C2776820930 @default.
• W2050253095 hasConceptScore W2050253095C2777798775 @default.
• W2050253095 hasConceptScore W2050253095C2778198053 @default.
• W2050253095 hasConceptScore W2050253095C2778742706 @default.
• W2050253095 hasConceptScore W2050253095C2780007613 @default.

• next