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- W2050259906 abstract "The subcellular distributions of the gamma- and beta II-subspecies of protein kinase C (gamma- and beta II-PKC) were studied in the rat hippocampus by light and electron microscopic immunocytochemistry. Both subspecies were abundant in the hippocampus with distinct subcellular distributions. The immunoreactivity of gamma-PKC was observed throughout the Ammon's horn, while intense beta II-PKC immunoreactivity was observed predominantly in the CA1 region. gamma-PKC was distributed diffusely through the cytoplasm of pyramidal cells from the perikarya to the dendritic spines. In contrast, beta II-PKC was concentrated around the Golgi complex and present diffusely in distal dendrites, except for the dendritic spines. Neither PKC subspecies could be detected in the presynaptic terminal. The postsynaptic localization of gamma- and beta II-PKC in CA1 suggests that both PKC subspecies may correlate to long-term potentiation in the CA1 region contributing to the postsynaptic side. gamma-PKC may have a specific function not only in CA1 but also in the mossy fiber-CA3 pathway at the postsynaptic side. beta II-PKC may have another function concerning the Golgi complex in CA1." @default.
- W2050259906 created "2016-06-24" @default.
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- W2050259906 date "1990-06-01" @default.
- W2050259906 modified "2023-10-13" @default.
- W2050259906 title "Electron microscopic localization of γ- and βII-subspecies of protein kinase C in rat hippocampus" @default.
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- W2050259906 doi "https://doi.org/10.1016/0006-8993(90)90974-g" @default.
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