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- W2050264927 abstract "Physostigmine (Phy), a reversible inhibitor of acetylcholine (ACh) esterase (AChE), may also act as a low potency agonist and a modulator of the nicotinic receptor. The actions of Phy on mouse muscle nicotinic receptors in the COS-7 cell line were studied by the patch-clamp technique. Currents were recorded in the whole-cell mode 3–7 days after cell transfection by plasmids coding αβγδ combination of receptor subunits. The application of ACh to cells clamped at −10 mV produced inward currents which displayed desensitization. The application of Phy in concentrations up to 1 × 10−3 M did not give reliable specific whole-cell membrane responses. The application of Phy in concentrations of 10−6–10−4 M together with ACh modulated the amplitude; accelerated desensitization of currents induced by ACh and increased the final extent of desensitization in a concentration-dependent manner. This finding is in contrast to the suppression and slowing down of desensitization by Phy and 1-methyl-galanthamine observed in Torpedo receptors." @default.
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- W2050264927 date "2006-06-01" @default.
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- W2050264927 title "Physostigmine modulation of acetylcholine currents in COS cells transfected with mouse muscle nicotinic receptor" @default.
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- W2050264927 doi "https://doi.org/10.1016/j.neulet.2006.02.065" @default.
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