Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050265655> ?p ?o ?g. }
- W2050265655 endingPage "1226" @default.
- W2050265655 startingPage "1218" @default.
- W2050265655 abstract "One of symptoms of transmissible spongiform encephalopathies is associated with the transformation of normal cellular prion protein, PrP, in its amyloid isoform resistant to proteolytic cleavage. The present study shows that interaction with copper ions converts both monomeric recombinant scrapie-susceptible PrP-VRQ and scrapie-resistant PrP-ARR variants into protease-resistant soluble oligomers with amyloid characteristics — dominant β-sheet secondary structure and interaction with thioflavine S. In contrast, binding of zinc ions resulting in the same resistance to proteolysis does not provoke transformation of α-helical monomeric structure of both PrP polymorphic variants. Cleavage of PrP N-terminus destabilises soluble form of such aggregates, and N-truncated PrPrec complexed with metal cations precipitate. N-truncated PrPrec complexed with Zn precipitated much faster than N-truncated PrPrec complexed with Cu. According to the hypothesis about the key role of small PrP oligomers in PrPC-PrPSc transformation, formation of soluble oligomers of PrP complexed with Cu can constitute an additional element in TSE propagation. Identical metal-chelating behaviour of two studied polymorphic PrPrec variants conferring different susceptibilities of sheep to scrapie could indicate their different capabilities to form fibrils. This could imply also that other factors than physico-chemical differences between PrP-VRQ and PrP-ARR and the differences in PrP transformation are responsible for the onset of TSE." @default.
- W2050265655 created "2016-06-24" @default.
- W2050265655 creator A5038633972 @default.
- W2050265655 creator A5047512281 @default.
- W2050265655 creator A5057470607 @default.
- W2050265655 creator A5064288910 @default.
- W2050265655 creator A5078884564 @default.
- W2050265655 creator A5079497279 @default.
- W2050265655 date "2006-07-01" @default.
- W2050265655 modified "2023-09-27" @default.
- W2050265655 title "Cu(II) induces small-size aggregates with amyloid characteristics in two alleles of recombinant ovine prion proteins" @default.
- W2050265655 cites W149247114 @default.
- W2050265655 cites W1550691248 @default.
- W2050265655 cites W1974443289 @default.
- W2050265655 cites W1976207582 @default.
- W2050265655 cites W1982164618 @default.
- W2050265655 cites W1984676214 @default.
- W2050265655 cites W1995247791 @default.
- W2050265655 cites W1996941571 @default.
- W2050265655 cites W1999180861 @default.
- W2050265655 cites W2007967965 @default.
- W2050265655 cites W2010715063 @default.
- W2050265655 cites W2012128918 @default.
- W2050265655 cites W2020066220 @default.
- W2050265655 cites W2022654057 @default.
- W2050265655 cites W2022735447 @default.
- W2050265655 cites W2030103154 @default.
- W2050265655 cites W2036221181 @default.
- W2050265655 cites W2038887966 @default.
- W2050265655 cites W2044531867 @default.
- W2050265655 cites W2051564837 @default.
- W2050265655 cites W2057293794 @default.
- W2050265655 cites W2058659733 @default.
- W2050265655 cites W2077281287 @default.
- W2050265655 cites W2084646890 @default.
- W2050265655 cites W2087275341 @default.
- W2050265655 cites W2090184114 @default.
- W2050265655 cites W2090844619 @default.
- W2050265655 cites W2100837269 @default.
- W2050265655 cites W2108078938 @default.
- W2050265655 cites W2122909430 @default.
- W2050265655 cites W2123321976 @default.
- W2050265655 cites W2124577524 @default.
- W2050265655 cites W2132661882 @default.
- W2050265655 cites W2138038687 @default.
- W2050265655 cites W2141663125 @default.
- W2050265655 cites W2150561211 @default.
- W2050265655 cites W2157980298 @default.
- W2050265655 cites W2324660492 @default.
- W2050265655 doi "https://doi.org/10.1016/j.bbapap.2006.04.013" @default.
- W2050265655 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16777497" @default.
- W2050265655 hasPublicationYear "2006" @default.
- W2050265655 type Work @default.
- W2050265655 sameAs 2050265655 @default.
- W2050265655 citedByCount "24" @default.
- W2050265655 countsByYear W20502656552012 @default.
- W2050265655 countsByYear W20502656552013 @default.
- W2050265655 countsByYear W20502656552014 @default.
- W2050265655 countsByYear W20502656552018 @default.
- W2050265655 countsByYear W20502656552021 @default.
- W2050265655 crossrefType "journal-article" @default.
- W2050265655 hasAuthorship W2050265655A5038633972 @default.
- W2050265655 hasAuthorship W2050265655A5047512281 @default.
- W2050265655 hasAuthorship W2050265655A5057470607 @default.
- W2050265655 hasAuthorship W2050265655A5064288910 @default.
- W2050265655 hasAuthorship W2050265655A5078884564 @default.
- W2050265655 hasAuthorship W2050265655A5079497279 @default.
- W2050265655 hasConcept C104317684 @default.
- W2050265655 hasConcept C12554922 @default.
- W2050265655 hasConcept C142724271 @default.
- W2050265655 hasConcept C151730666 @default.
- W2050265655 hasConcept C166940927 @default.
- W2050265655 hasConcept C175156509 @default.
- W2050265655 hasConcept C178790620 @default.
- W2050265655 hasConcept C179104552 @default.
- W2050265655 hasConcept C181199279 @default.
- W2050265655 hasConcept C185592680 @default.
- W2050265655 hasConcept C202751555 @default.
- W2050265655 hasConcept C204241405 @default.
- W2050265655 hasConcept C27523624 @default.
- W2050265655 hasConcept C2776735649 @default.
- W2050265655 hasConcept C2777633098 @default.
- W2050265655 hasConcept C2779134260 @default.
- W2050265655 hasConcept C2781307694 @default.
- W2050265655 hasConcept C3019804061 @default.
- W2050265655 hasConcept C40767141 @default.
- W2050265655 hasConcept C43369102 @default.
- W2050265655 hasConcept C521977710 @default.
- W2050265655 hasConcept C53345823 @default.
- W2050265655 hasConcept C55493867 @default.
- W2050265655 hasConcept C71924100 @default.
- W2050265655 hasConcept C86803240 @default.
- W2050265655 hasConceptScore W2050265655C104317684 @default.
- W2050265655 hasConceptScore W2050265655C12554922 @default.
- W2050265655 hasConceptScore W2050265655C142724271 @default.
- W2050265655 hasConceptScore W2050265655C151730666 @default.
- W2050265655 hasConceptScore W2050265655C166940927 @default.
- W2050265655 hasConceptScore W2050265655C175156509 @default.