FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050269323> ?p ?o ?g. }

• W2050269323 endingPage "8879" @default.
• W2050269323 startingPage "8871" @default.
• W2050269323 abstract "The mazEF homologs of Staphylococcus aureus, designated mazEF(sa), have been shown to cotranscribe with the sigB operon under stress conditions. In this study, we showed that MazEF(Sa), as with their Escherichia coli counterparts, compose a toxin-antitoxin module wherein MazF(Sa) leads to rapid cell growth arrest and loss in viable CFU upon overexpression. MazF(Sa) is a novel sequence-specific endoribonuclease which cleaves mRNA to inhibit protein synthesis. Using ctpA mRNA as the model substrate both in vitro and in vivo, we demonstrated that MazF(Sa) cleaves single-strand RNA preferentially at the 5' side of the first U or 3' side of the second U residue within the consensus sequences VUUV' (where V and V' are A, C, or G and may or may not be identical). Binding studies confirmed that the antitoxin MazE(Sa) binds MazF(Sa) to form a complex to inhibit the endoribonuclease activity of MazF(Sa). Contrary to the system in E. coli, exposure to selected antibiotics augmented mazEF(sa) transcription, akin to what one would anticipate from the environmental stress response of the sigB system. These data indicate that the mazEF system of S. aureus differs from the gram-negative counterparts with respect to mRNA cleavage specificity and antibiotic stresses." @default.
• W2050269323 created "2016-06-24" @default.
• W2050269323 creator A5000920238 @default.
• W2050269323 creator A5030198159 @default.
• W2050269323 creator A5082360434 @default.
• W2050269323 creator A5084406971 @default.
• W2050269323 date "2007-12-15" @default.
• W2050269323 modified "2023-10-01" @default.
• W2050269323 title "Characterization of MazF _<i>Sa</i> , an Endoribonuclease from <i>Staphylococcus aureus</i>" @default.
• W2050269323 cites W1604915411 @default.
• W2050269323 cites W1742461086 @default.
• W2050269323 cites W1820567505 @default.
• W2050269323 cites W1947624003 @default.
• W2050269323 cites W1965803013 @default.
• W2050269323 cites W1970783326 @default.
• W2050269323 cites W1981369154 @default.
• W2050269323 cites W1982777646 @default.
• W2050269323 cites W1985347638 @default.
• W2050269323 cites W1986029743 @default.
• W2050269323 cites W1988020173 @default.
• W2050269323 cites W2008207070 @default.
• W2050269323 cites W2015442594 @default.
• W2050269323 cites W2017550427 @default.
• W2050269323 cites W2028586204 @default.
• W2050269323 cites W2050634720 @default.
• W2050269323 cites W2053564897 @default.
• W2050269323 cites W2059303607 @default.
• W2050269323 cites W2065754101 @default.
• W2050269323 cites W2067148638 @default.
• W2050269323 cites W2075518131 @default.
• W2050269323 cites W2076809355 @default.
• W2050269323 cites W2083873972 @default.
• W2050269323 cites W2093814623 @default.
• W2050269323 cites W2101885597 @default.
• W2050269323 cites W2109572234 @default.
• W2050269323 cites W2111555302 @default.
• W2050269323 cites W2114022811 @default.
• W2050269323 cites W2115601383 @default.
• W2050269323 cites W2116210469 @default.
• W2050269323 cites W2122386566 @default.
• W2050269323 cites W2138808082 @default.
• W2050269323 cites W2138826967 @default.
• W2050269323 cites W2145589671 @default.
• W2050269323 cites W2154964144 @default.
• W2050269323 cites W2156539285 @default.
• W2050269323 cites W2160084442 @default.
• W2050269323 doi "https://doi.org/10.1128/jb.01272-07" @default.
• W2050269323 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2168618" @default.
• W2050269323 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17933891" @default.
• W2050269323 hasPublicationYear "2007" @default.
• W2050269323 type Work @default.
• W2050269323 sameAs 2050269323 @default.
• W2050269323 citedByCount "72" @default.
• W2050269323 countsByYear W20502693232012 @default.
• W2050269323 countsByYear W20502693232013 @default.
• W2050269323 countsByYear W20502693232014 @default.
• W2050269323 countsByYear W20502693232015 @default.
• W2050269323 countsByYear W20502693232016 @default.
• W2050269323 countsByYear W20502693232017 @default.
• W2050269323 countsByYear W20502693232018 @default.
• W2050269323 countsByYear W20502693232019 @default.
• W2050269323 countsByYear W20502693232020 @default.
• W2050269323 countsByYear W20502693232021 @default.
• W2050269323 countsByYear W20502693232023 @default.
• W2050269323 crossrefType "journal-article" @default.
• W2050269323 hasAuthorship W2050269323A5000920238 @default.
• W2050269323 hasAuthorship W2050269323A5030198159 @default.
• W2050269323 hasAuthorship W2050269323A5082360434 @default.
• W2050269323 hasAuthorship W2050269323A5084406971 @default.
• W2050269323 hasBestOaLocation W20502693232 @default.
• W2050269323 hasConcept C104317684 @default.
• W2050269323 hasConcept C105580179 @default.
• W2050269323 hasConcept C10879258 @default.
• W2050269323 hasConcept C138885662 @default.
• W2050269323 hasConcept C153911025 @default.
• W2050269323 hasConcept C179926584 @default.
• W2050269323 hasConcept C202751555 @default.
• W2050269323 hasConcept C203075996 @default.
• W2050269323 hasConcept C2777367657 @default.
• W2050269323 hasConcept C2778973234 @default.
• W2050269323 hasConcept C2779489039 @default.
• W2050269323 hasConcept C2780102198 @default.
• W2050269323 hasConcept C41895202 @default.
• W2050269323 hasConcept C523546767 @default.
• W2050269323 hasConcept C54355233 @default.
• W2050269323 hasConcept C547475151 @default.
• W2050269323 hasConcept C55493867 @default.
• W2050269323 hasConcept C67705224 @default.
• W2050269323 hasConcept C86803240 @default.
• W2050269323 hasConcept C89423630 @default.
• W2050269323 hasConceptScore W2050269323C104317684 @default.
• W2050269323 hasConceptScore W2050269323C105580179 @default.
• W2050269323 hasConceptScore W2050269323C10879258 @default.
• W2050269323 hasConceptScore W2050269323C138885662 @default.
• W2050269323 hasConceptScore W2050269323C153911025 @default.
• W2050269323 hasConceptScore W2050269323C179926584 @default.
• W2050269323 hasConceptScore W2050269323C202751555 @default.
• W2050269323 hasConceptScore W2050269323C203075996 @default.

• next