Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050274226> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2050274226 endingPage "426" @default.
- W2050274226 startingPage "421" @default.
- W2050274226 abstract "The identification of growth factors and/or receptors produced by mammalian embryos or present in the maternal reproductive tract is of basic interest, as well as having practical application. Early studies established that receptors binding insulin and the insulin-like growth factors (IGFs) are expressed by preimplantation mouse embryos. These studies have been confirmed at the molecular level using RT-PCR techniques. In addition, high resolution electron microscopy has shown that insulin is internalized by the cells of the blastocyst stage mouse embryo, and that immunologically intact insulin is detectable in the cells of the trophectoderm and inner cell mass. Similar studies with gold labelled IGF-I have shown that this ligand is also bound and internalized by mouse blastocysts. However, although all blastocysts express receptors that bind IGF-I on the basolateral cell surface of the trophectoderm, only 30% exhibit apically located receptors. In order to elucidate the functions of IGFs in early mouse development, we are in the process of constructing protein data-bases for embryos at the eight-cell and blastocyst stage. By the use of the database, it should prove possible to elucidate targets of growth factor action." @default.
- W2050274226 created "2016-06-24" @default.
- W2050274226 creator A5050765927 @default.
- W2050274226 creator A5053838409 @default.
- W2050274226 creator A5057271826 @default.
- W2050274226 creator A5079469120 @default.
- W2050274226 date "1993-08-01" @default.
- W2050274226 modified "2023-10-09" @default.
- W2050274226 title "Functions of the IGFs in early mammalian development" @default.
- W2050274226 cites W1712601943 @default.
- W2050274226 cites W1982469653 @default.
- W2050274226 cites W2004978370 @default.
- W2050274226 cites W2020266305 @default.
- W2050274226 cites W2049136532 @default.
- W2050274226 cites W2058203091 @default.
- W2050274226 cites W2116073351 @default.
- W2050274226 cites W2133930018 @default.
- W2050274226 cites W2147998224 @default.
- W2050274226 cites W2184019788 @default.
- W2050274226 cites W2244774491 @default.
- W2050274226 doi "https://doi.org/10.1002/mrd.1080350417" @default.
- W2050274226 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8398122" @default.
- W2050274226 hasPublicationYear "1993" @default.
- W2050274226 type Work @default.
- W2050274226 sameAs 2050274226 @default.
- W2050274226 citedByCount "24" @default.
- W2050274226 countsByYear W20502742262013 @default.
- W2050274226 countsByYear W20502742262015 @default.
- W2050274226 countsByYear W20502742262019 @default.
- W2050274226 crossrefType "journal-article" @default.
- W2050274226 hasAuthorship W2050274226A5050765927 @default.
- W2050274226 hasAuthorship W2050274226A5053838409 @default.
- W2050274226 hasAuthorship W2050274226A5057271826 @default.
- W2050274226 hasAuthorship W2050274226A5079469120 @default.
- W2050274226 hasConcept C126322002 @default.
- W2050274226 hasConcept C134018914 @default.
- W2050274226 hasConcept C1491633281 @default.
- W2050274226 hasConcept C159399396 @default.
- W2050274226 hasConcept C170493617 @default.
- W2050274226 hasConcept C196843134 @default.
- W2050274226 hasConcept C2778177303 @default.
- W2050274226 hasConcept C2779306644 @default.
- W2050274226 hasConcept C54355233 @default.
- W2050274226 hasConcept C71924100 @default.
- W2050274226 hasConcept C86803240 @default.
- W2050274226 hasConcept C87073359 @default.
- W2050274226 hasConcept C95444343 @default.
- W2050274226 hasConceptScore W2050274226C126322002 @default.
- W2050274226 hasConceptScore W2050274226C134018914 @default.
- W2050274226 hasConceptScore W2050274226C1491633281 @default.
- W2050274226 hasConceptScore W2050274226C159399396 @default.
- W2050274226 hasConceptScore W2050274226C170493617 @default.
- W2050274226 hasConceptScore W2050274226C196843134 @default.
- W2050274226 hasConceptScore W2050274226C2778177303 @default.
- W2050274226 hasConceptScore W2050274226C2779306644 @default.
- W2050274226 hasConceptScore W2050274226C54355233 @default.
- W2050274226 hasConceptScore W2050274226C71924100 @default.
- W2050274226 hasConceptScore W2050274226C86803240 @default.
- W2050274226 hasConceptScore W2050274226C87073359 @default.
- W2050274226 hasConceptScore W2050274226C95444343 @default.
- W2050274226 hasIssue "4" @default.
- W2050274226 hasLocation W20502742261 @default.
- W2050274226 hasLocation W20502742262 @default.
- W2050274226 hasOpenAccess W2050274226 @default.
- W2050274226 hasPrimaryLocation W20502742261 @default.
- W2050274226 hasRelatedWork W1515059751 @default.
- W2050274226 hasRelatedWork W1667830006 @default.
- W2050274226 hasRelatedWork W1990243394 @default.
- W2050274226 hasRelatedWork W2013170634 @default.
- W2050274226 hasRelatedWork W2099138420 @default.
- W2050274226 hasRelatedWork W2151872057 @default.
- W2050274226 hasRelatedWork W2299890764 @default.
- W2050274226 hasRelatedWork W2900356592 @default.
- W2050274226 hasRelatedWork W2934111382 @default.
- W2050274226 hasRelatedWork W4250377422 @default.
- W2050274226 hasVolume "35" @default.
- W2050274226 isParatext "false" @default.
- W2050274226 isRetracted "false" @default.
- W2050274226 magId "2050274226" @default.
- W2050274226 workType "article" @default.