Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050280455> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2050280455 endingPage "113" @default.
- W2050280455 startingPage "107" @default.
- W2050280455 abstract "We investigated the possible use of a local chemotherapy in the treatment of malignant lesions in bone. Therefore, the diffusion of cisplatin from polymethyl methacrylate implants was studied in vitro and in vivo in rabbits. Cisplatin-loaded implants were prepared by extemporaneous polymerization of methyl methacrylate added to a poly (methyl methacrylate)/drug blending. The in vitro release rate of cisplatin was very slow and incomplete, but increased when the drug loading was higher, suggesting a percolation release model. In vivo, drug-loaded implants showed sustained release characteristics and no plasma peak, compared to control intravenous cisplatin administration. After implantation, local concentrations of platinum were higher in bone marrow than in bone tissue. Comparative safety studies with cisplatin infusion showed a slight, but not clinically significant, renal and haematologic toxicity for drug-loaded implants." @default.
- W2050280455 created "2016-06-24" @default.
- W2050280455 creator A5006207822 @default.
- W2050280455 creator A5010594374 @default.
- W2050280455 creator A5022289905 @default.
- W2050280455 creator A5022296347 @default.
- W2050280455 creator A5041610975 @default.
- W2050280455 date "1995-01-01" @default.
- W2050280455 modified "2023-10-18" @default.
- W2050280455 title "Cisplatin-loaded poly (methyl methacrylate) implants: a sustained drug delivery system" @default.
- W2050280455 cites W1905716198 @default.
- W2050280455 cites W2016558485 @default.
- W2050280455 cites W2039308630 @default.
- W2050280455 cites W2039919631 @default.
- W2050280455 cites W2049056293 @default.
- W2050280455 cites W2059547417 @default.
- W2050280455 cites W2312861022 @default.
- W2050280455 cites W4301224389 @default.
- W2050280455 doi "https://doi.org/10.1016/0168-3659(94)00077-8" @default.
- W2050280455 hasPublicationYear "1995" @default.
- W2050280455 type Work @default.
- W2050280455 sameAs 2050280455 @default.
- W2050280455 citedByCount "21" @default.
- W2050280455 countsByYear W20502804552013 @default.
- W2050280455 countsByYear W20502804552015 @default.
- W2050280455 countsByYear W20502804552016 @default.
- W2050280455 countsByYear W20502804552018 @default.
- W2050280455 countsByYear W20502804552019 @default.
- W2050280455 countsByYear W20502804552020 @default.
- W2050280455 countsByYear W20502804552021 @default.
- W2050280455 countsByYear W20502804552022 @default.
- W2050280455 crossrefType "journal-article" @default.
- W2050280455 hasAuthorship W2050280455A5006207822 @default.
- W2050280455 hasAuthorship W2050280455A5010594374 @default.
- W2050280455 hasAuthorship W2050280455A5022289905 @default.
- W2050280455 hasAuthorship W2050280455A5022296347 @default.
- W2050280455 hasAuthorship W2050280455A5041610975 @default.
- W2050280455 hasConcept C112705442 @default.
- W2050280455 hasConcept C136229726 @default.
- W2050280455 hasConcept C141071460 @default.
- W2050280455 hasConcept C150903083 @default.
- W2050280455 hasConcept C178790620 @default.
- W2050280455 hasConcept C185592680 @default.
- W2050280455 hasConcept C202751555 @default.
- W2050280455 hasConcept C207001950 @default.
- W2050280455 hasConcept C2776694085 @default.
- W2050280455 hasConcept C2777935641 @default.
- W2050280455 hasConcept C2778239845 @default.
- W2050280455 hasConcept C2779820397 @default.
- W2050280455 hasConcept C2780035454 @default.
- W2050280455 hasConcept C29730261 @default.
- W2050280455 hasConcept C44228677 @default.
- W2050280455 hasConcept C521977710 @default.
- W2050280455 hasConcept C55493867 @default.
- W2050280455 hasConcept C71924100 @default.
- W2050280455 hasConcept C86803240 @default.
- W2050280455 hasConcept C98274493 @default.
- W2050280455 hasConceptScore W2050280455C112705442 @default.
- W2050280455 hasConceptScore W2050280455C136229726 @default.
- W2050280455 hasConceptScore W2050280455C141071460 @default.
- W2050280455 hasConceptScore W2050280455C150903083 @default.
- W2050280455 hasConceptScore W2050280455C178790620 @default.
- W2050280455 hasConceptScore W2050280455C185592680 @default.
- W2050280455 hasConceptScore W2050280455C202751555 @default.
- W2050280455 hasConceptScore W2050280455C207001950 @default.
- W2050280455 hasConceptScore W2050280455C2776694085 @default.
- W2050280455 hasConceptScore W2050280455C2777935641 @default.
- W2050280455 hasConceptScore W2050280455C2778239845 @default.
- W2050280455 hasConceptScore W2050280455C2779820397 @default.
- W2050280455 hasConceptScore W2050280455C2780035454 @default.
- W2050280455 hasConceptScore W2050280455C29730261 @default.
- W2050280455 hasConceptScore W2050280455C44228677 @default.
- W2050280455 hasConceptScore W2050280455C521977710 @default.
- W2050280455 hasConceptScore W2050280455C55493867 @default.
- W2050280455 hasConceptScore W2050280455C71924100 @default.
- W2050280455 hasConceptScore W2050280455C86803240 @default.
- W2050280455 hasConceptScore W2050280455C98274493 @default.
- W2050280455 hasIssue "1" @default.
- W2050280455 hasLocation W20502804551 @default.
- W2050280455 hasOpenAccess W2050280455 @default.
- W2050280455 hasPrimaryLocation W20502804551 @default.
- W2050280455 hasRelatedWork W1491964893 @default.
- W2050280455 hasRelatedWork W1973476314 @default.
- W2050280455 hasRelatedWork W2004556784 @default.
- W2050280455 hasRelatedWork W2006425566 @default.
- W2050280455 hasRelatedWork W2094219250 @default.
- W2050280455 hasRelatedWork W2379311614 @default.
- W2050280455 hasRelatedWork W2388069209 @default.
- W2050280455 hasRelatedWork W2407812582 @default.
- W2050280455 hasRelatedWork W2582907174 @default.
- W2050280455 hasRelatedWork W2753834235 @default.
- W2050280455 hasVolume "33" @default.
- W2050280455 isParatext "false" @default.
- W2050280455 isRetracted "false" @default.
- W2050280455 magId "2050280455" @default.
- W2050280455 workType "article" @default.