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• W2050301097 abstract "The importance of the large number of thin-diameter and unmyelinated axons that connect different cortical areas is unknown. The pronounced propagation delays in these axons may prevent synchronization of cortical networks and therefore hinder efficient information integration and processing. Yet, such global information integration across cortical areas is vital for higher cognitive function. We hypothesized that delays in communication between cortical areas can disrupt synchronization and therefore enhance the set of activity trajectories and computations interconnected networks can perform. To evaluate this hypothesis, we studied the effect of long-range cortical projections with propagation delays in interconnected large-scale cortical networks that exhibited spontaneous rhythmic activity. Long-range connections with delays caused the emergence of metastable, spatio-temporally distinct activity states between which the networks spontaneously transitioned. Interestingly, the observed activity patterns correspond to macroscopic network dynamics such as globally synchronized activity, propagating wave fronts, and spiral waves that have been previously observed in neurophysiological recordings from humans and animal models. Transient perturbations with simulated transcranial alternating current stimulation (tACS) confirmed the multistability of the interconnected networks by switching the networks between these metastable states. Our model thus proposes that slower long-range connections enrich the landscape of activity states and represent a parsimonious mechanism for the emergence of multistability in cortical networks. These results further provide a mechanistic link between the known deficits in connectivity and cortical state dynamics in neuropsychiatric illnesses such as schizophrenia and autism, as well as suggest non-invasive brain stimulation as an effective treatment for these illnesses." @default.
• W2050301097 created "2016-06-24" @default.
• W2050301097 creator A5064845004 @default.
• W2050301097 creator A5088913727 @default.
• W2050301097 date "2013-10-24" @default.
• W2050301097 modified "2023-10-16" @default.
• W2050301097 title "Emergence of Metastable State Dynamics in Interconnected Cortical Networks with Propagation Delays" @default.
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• W2050301097 doi "https://doi.org/10.1371/journal.pcbi.1003304" @default.
• W2050301097 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3812055" @default.
• W2050301097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24204238" @default.
• W2050301097 hasPublicationYear "2013" @default.
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