FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050326353> ?p ?o ?g. }

• W2050326353 endingPage "687" @default.
• W2050326353 startingPage "679" @default.
• W2050326353 abstract "Alveolar macrophages (AM) are the first line of defense against infection in the lungs. We previously showed that the production of superoxide and hydrogen peroxide, i.e., the respiratory burst, is stimulated by adenine nucleotides (ADP >> ATP) in rat AM through signaling pathways involving calcium and protein kinase C. Here, we further show that ADP induces a rapid increase in the tyrosine phosphorylation of several proteins that was reduced by the tyrosine kinase inhibitor genistein, which also inhibited the respiratory burst. Interestingly, ADP did not trigger the activation of the mitogen-activated protein kinases ERK1 and ERK2, or that of protein kinase B/AKT, a downstream target of the phosphatidylinositol 3-kinase (PI3K) pathway. This is in contrast to another stimulus of the respiratory burst, zymosan-activated serum (ZAS), which activates both the ERK and PI3K pathways. Thus, this study demonstrates that the receptor for ADP in rat AM is not coupled to the ERK and AKT pathways and, that neither the ERK pathway nor AKT is essential to induce the activation of the NAPDH oxidase by ADP in rat AM while tyrosine kinases appeared to be required. The rate and amount of hydrogen peroxide released by the ADP-stimulated respiratory burst was similar to that produced by ZAS stimulation. The absence of ERK activation after ADP stimulation therefore suggests that hydrogen peroxide is not sufficient to activate the ERK pathway in rat AM. Nonetheless, as hydrogen peroxide was necessary for ERK activation by ZAS, this indicates that, in contrast to ADP, ZAS stimulates a pathway that is targeted by hydrogen peroxide and leads to ERK activation." @default.
• W2050326353 created "2016-06-24" @default.
• W2050326353 creator A5040372208 @default.
• W2050326353 creator A5056799133 @default.
• W2050326353 creator A5077204648 @default.
• W2050326353 date "2001-09-01" @default.
• W2050326353 modified "2023-09-27" @default.
• W2050326353 title "ADP stimulates the respiratory burst without activation of ERK and AKT in rat alveolar macrophages" @default.
• W2050326353 cites W127317704 @default.
• W2050326353 cites W138509909 @default.
• W2050326353 cites W1497341558 @default.
• W2050326353 cites W1515575932 @default.
• W2050326353 cites W1525942467 @default.
• W2050326353 cites W1530792946 @default.
• W2050326353 cites W1540271729 @default.
• W2050326353 cites W1578187871 @default.
• W2050326353 cites W1586099293 @default.
• W2050326353 cites W1631597983 @default.
• W2050326353 cites W1656644300 @default.
• W2050326353 cites W1751283081 @default.
• W2050326353 cites W1791888878 @default.
• W2050326353 cites W1815757713 @default.
• W2050326353 cites W1832014310 @default.
• W2050326353 cites W1861890207 @default.
• W2050326353 cites W1965167661 @default.
• W2050326353 cites W1968542957 @default.
• W2050326353 cites W1968985837 @default.
• W2050326353 cites W1973614704 @default.
• W2050326353 cites W1979987404 @default.
• W2050326353 cites W1980249181 @default.
• W2050326353 cites W1997990428 @default.
• W2050326353 cites W2010489503 @default.
• W2050326353 cites W2018724588 @default.
• W2050326353 cites W2027703981 @default.
• W2050326353 cites W2036451354 @default.
• W2050326353 cites W2045074115 @default.
• W2050326353 cites W2046867705 @default.
• W2050326353 cites W2047826668 @default.
• W2050326353 cites W2048569323 @default.
• W2050326353 cites W2050890727 @default.
• W2050326353 cites W2060236942 @default.
• W2050326353 cites W2061440101 @default.
• W2050326353 cites W2078564480 @default.
• W2050326353 cites W2089783130 @default.
• W2050326353 cites W2094317942 @default.
• W2050326353 cites W2095420861 @default.
• W2050326353 cites W2098719212 @default.
• W2050326353 cites W2101537600 @default.
• W2050326353 cites W2101840637 @default.
• W2050326353 cites W2109311512 @default.
• W2050326353 cites W2123085934 @default.
• W2050326353 cites W2127618101 @default.
• W2050326353 cites W2134030137 @default.
• W2050326353 cites W2149851012 @default.
• W2050326353 cites W2151683047 @default.
• W2050326353 cites W2184458566 @default.
• W2050326353 cites W2272359268 @default.
• W2050326353 cites W2328643786 @default.
• W2050326353 cites W2399591470 @default.
• W2050326353 cites W2418147382 @default.
• W2050326353 cites W273953136 @default.
• W2050326353 doi "https://doi.org/10.1016/s0891-5849(01)00630-x" @default.
• W2050326353 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11522453" @default.
• W2050326353 hasPublicationYear "2001" @default.
• W2050326353 type Work @default.
• W2050326353 sameAs 2050326353 @default.
• W2050326353 citedByCount "17" @default.
• W2050326353 countsByYear W20503263532012 @default.
• W2050326353 crossrefType "journal-article" @default.
• W2050326353 hasAuthorship W2050326353A5040372208 @default.
• W2050326353 hasAuthorship W2050326353A5056799133 @default.
• W2050326353 hasAuthorship W2050326353A5077204648 @default.
• W2050326353 hasConcept C11960822 @default.
• W2050326353 hasConcept C184235292 @default.
• W2050326353 hasConcept C185592680 @default.
• W2050326353 hasConcept C55493867 @default.
• W2050326353 hasConcept C57074206 @default.
• W2050326353 hasConcept C75217442 @default.
• W2050326353 hasConcept C86803240 @default.
• W2050326353 hasConcept C95444343 @default.
• W2050326353 hasConcept C99971728 @default.
• W2050326353 hasConceptScore W2050326353C11960822 @default.
• W2050326353 hasConceptScore W2050326353C184235292 @default.
• W2050326353 hasConceptScore W2050326353C185592680 @default.
• W2050326353 hasConceptScore W2050326353C55493867 @default.
• W2050326353 hasConceptScore W2050326353C57074206 @default.
• W2050326353 hasConceptScore W2050326353C75217442 @default.
• W2050326353 hasConceptScore W2050326353C86803240 @default.
• W2050326353 hasConceptScore W2050326353C95444343 @default.
• W2050326353 hasConceptScore W2050326353C99971728 @default.
• W2050326353 hasIssue "5" @default.
• W2050326353 hasLocation W20503263531 @default.
• W2050326353 hasLocation W20503263532 @default.
• W2050326353 hasOpenAccess W2050326353 @default.
• W2050326353 hasPrimaryLocation W20503263531 @default.
• W2050326353 hasRelatedWork W1952088202 @default.
• W2050326353 hasRelatedWork W2006105451 @default.
• W2050326353 hasRelatedWork W2010942875 @default.

• next