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• W2050340957 abstract "The maturation of animal oocytes is highly sensitive to nutrient availability. During Drosophila oogenesis, a prominent metabolic checkpoint occurs at the onset of yolk uptake (vitellogenesis): under nutrient stress, egg chambers degenerate by apoptosis. To investigate additional responses to nutrient deprivation, we studied the intercellular transport of cytoplasmic components between nurse cells and the oocyte during previtellogenic stages. Using GFP protein-traps, we showed that Ypsilon Schachtel (Yps), a putative RNA binding protein, moved into the oocyte by both microtubule (MT)-dependent and -independent mechanisms, and was retained in the oocyte in a MT-dependent manner. These data suggest that oocyte enrichment is accomplished by a combination of MT-dependent polarized transport and MT-independent flow coupled with MT-dependent trapping within the oocyte. Under nutrient stress, Yps and other components of the oskar ribonucleoprotein complex accumulated in large processing bodies in nurse cells, accompanied by MT reorganization. This response was detected as early as 2 h after starvation, suggesting that young egg chambers rapidly respond to nutrient stress. Moreover, both Yps aggregation and MT reorganization were reversed with re-feeding of females or the addition of exogenous insulin to cultured egg chambers. Our results suggest that egg chambers rapidly mount a stress response by altering intercellular transport upon starvation. This response implies a mechanism for preserving young egg chambers so that egg production can rapidly resume when nutrient availability improves." @default.
• W2050340957 created "2016-06-24" @default.
• W2050340957 creator A5006100220 @default.
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• W2050340957 date "2011-07-01" @default.
• W2050340957 modified "2023-10-18" @default.
• W2050340957 title "Reversible response of protein localization and microtubule organization to nutrient stress during Drosophila early oogenesis" @default.
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• W2050340957 doi "https://doi.org/10.1016/j.ydbio.2011.04.022" @default.
• W2050340957 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3118931" @default.
• W2050340957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21570389" @default.
• W2050340957 hasPublicationYear "2011" @default.
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