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- W2050355037 abstract "Melatonin and its precursor, N-acetylserotonin (NAS), have been shown in in vivo and in vitro studies to inhibit iron- and lipopolysaccharide (LPS)-induced lipid peroxidation in rats and mice. Using in vitro studies, we examined whether these effects will be affected by the melatonin receptor antagonists luzindole (a competitive MT(1)/MT(2) antagonist), DH 97 (MT(2)), prazosin (MT(3)), and 4-P-PDOT (MT(2)). Lipid peroxidation in the form of malondialdehyde (MDA) was assayed by measuring thiobarbituric acid-reactive substances. The antagonists did not affect the melatonin and NAS effect on iron- and LPS-induced peroxidation. However, luzindole alone, but not the other antagonists, inhibited the iron- and LPS-induced peroxidation in the rat brain and kidney homogenates. At a dose of 50 microM, luzindole reduced iron-induced MDA levels by 80% in the brain and 84% in the kidney, whereas LPS-induced MDA levels were reduced by 85% in both brain and kidney. A dose of 800 microM prevented lipid peroxidation, bringing the MDA levels to values of samples untreated by iron or LPS." @default.
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- W2050355037 date "2007-12-01" @default.
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- W2050355037 title "Effect of Luzindole and Other Melatonin Receptor Antagonists on Iron- and Lipopolysaccharide-Induced Lipid Peroxidation<i>in Vitro</i>" @default.
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- W2050355037 doi "https://doi.org/10.1196/annals.1403.021" @default.
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