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- W2050355607 abstract "The effects of estetrol (E4), a natural fetal estrogen, combined with drospirenone (DRSP) were evaluated on plasma levels of sex hormone-binding globulin (SHBG), angiotensinogen and 12 hemostasis markers.Combinations of 3 mg DRSP with 5 or 10 mg E4 were compared with YAZ® (20 mcg ethinyl estradiol and 3 mg DRSP; EE/DRSP) in parallel groups of 15–18 healthy young women. Main outcome was the relative change from pretreatment to the end (day 24±1) of the third treatment cycle.All E4 combinations showed low estrogen impact compared to EE/DRSP. Effects on SHBG and angiotensinogen of 10 mg E4 combined with DRSP were 15%–20% that of EE/DRSP.Both E4/DRSP combinations reduced D-dimer level and the 5 mg E4/DRSP combination also decreased fragment 1+2.The reduction in coagulation markers suggests an anticoagulant effect from DRSP.The indications of a low thrombosis risk for E4 preparations should be validated in larger studies.•The oral estrogens, 17-β-estradiol and ethinyl estradiol, are known for significant effects on estrogenic and hemostatic variables.•Effects of oral estetrol (E4) combined with drospirenone (DRSP) are significantly less for these variables.•This suggests a low procoagulant effect of E4/DRSP that should be clinically verified for low antithrombotic consequences." @default.
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- W2050355607 date "2005-04-01" @default.
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- W2050355607 title "T04-P-039 The role of plasma homocysteine levelon collateral status in single-vessel chronic total occlusion" @default.
- W2050355607 doi "https://doi.org/10.1016/s1567-5688(05)80630-0" @default.
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