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• W2050357506 abstract "Abstract Complex I (NADH-ubiquinone reductase) and Complex III (ubiquinol-cytochrome c reductase) supplemented with NADH generated O 2 − at maximum rates of 9.8 and 6.5 nmol/min/mg of protein, respectively, while, in the presence of superoxide dismutase, the same systems generated H 2 O 2 at maximum rates of 5.1 and 4.2 nmol/min/mg of protein, respectively. H 2 O 2 was essentially produced by disproportionation of O 2 − , which constitutes the precursor of H 2 O 2 . The effectiveness of the generation of oxygen intermediates by Complex I in the absence of other specific electron acceptors was 0.95 mol of O 2 − and 0.63 mol of H 2 O 2 /mol of NADH. A reduced form of ubiquinone appeared to be responsible for the reduction of O 2 to O 2 − , since (a) ubiquinone constituted the sole common major component of Complexes I and III, (b) H 2 O 2 generation by Complex I was inhibited by rotenone, and (c) supplementation of Complex I with exogenous ubiquinones increased the rate of H 2 O 2 generation. The efficiency of added quinones as peroxide generators decreased in the order Q 1 > Q 0 > Q 2 > Q 6 = Q 10 , in agreement with the quinone capacity of acting as electron acceptor for Complex I. In the supplemented systems, the exogenous quinone was reduced by Complex I and oxidized nonenzymatically by molecular oxygen. Additional evidence for the role of ubiquinone as peroxide generator is provided by the generation of O 2 − and H 2 O 2 during autoxidation of quinols. In oxygenated buffers, ubiquinol (Q 0 H 2 ), benzoquinol, duroquinol and menadiol generated O 2 − with k 3 values of 0.1 to 1.4 m − · s −1 and H 2 O 2 with k 4 values of 0.009 to 4.3 m −1 · s −1 ." @default.
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• W2050357506 date "1977-04-01" @default.
• W2050357506 modified "2023-10-13" @default.
• W2050357506 title "Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria" @default.
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• W2050357506 doi "https://doi.org/10.1016/0003-9861(77)90035-2" @default.
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