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- W2050375961 abstract "The distribution of methylmercury (MeHg) in subcellular organelles of the rat brain varied slightly in relation to the in vivo or the in vitro mode of labeling with Me203HgCl. The differences may be explained by disruption of the normal diffusion path into the brain cells and the amount of MeHg that is bound along this diffusion path. When Me203Hg and [3H]QNB (quinuclidinyl benzilate) were added directly to brain homogenates, the subcellular fractions demonstrated a molar rmQNBMeHg binding ratio greater than 1:100. This suggests that MeHg binding sites are in considerable excess over QNB binding sites and represent a relatively large sink for decreasing effective MeHg concentration. HgCl2 was 100 times as potent as MeHg for blocking specific QNB binding sites. (MeHg, ID50 = 10−5 m; HgCl2, ID50 = 10−7 m) On the basis of the respective ID50 points, a 1% conversion of MeHg to the inorganic form would produce a separate but equivalent block of muscarinic binding sites. Therefore, it is suggested that the early theory involving organic to inorganic Hg conversion be reexamined as a possibility for producing the selective toxicity to the central nervous system observed in cases of MeHg poisoning." @default.
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- W2050375961 date "1980-04-01" @default.
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- W2050375961 title "Methylmercury inhibition of rat brain muscarinic receptors" @default.
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- W2050375961 doi "https://doi.org/10.1016/0041-008x(80)90428-7" @default.
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