FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050389359> ?p ?o ?g. }

• W2050389359 endingPage "6723" @default.
• W2050389359 startingPage "6712" @default.
• W2050389359 abstract "Decreased albumin expression is a frequent feature of cachexia patients afflicted with chronic diseases, including cancer, and a major contributor to their morbidity. Here we show that tumor necrosis-alpha (TNF-alpha) treatment of primary mouse hepatocytes or TNF-alpha overexpression in a mouse model of cachexia induces oxidative stress, nitric oxide synthase (NOS) expression and phosphorylation of C/EBPbeta on Ser239, within the nuclear localization signal, thus inducing its nuclear export, which inhibits transcription from the albumin gene. SIN-1, a NO donor, duplicated the TNF-alpha effects on hepatocytes. We found similar molecular abnormalities in the liver of patients with cancer-cachexia. The cytoplasmic localization and association of C/EBPbeta-PSer239 with CRM1 (exportin-1) in TNF-alpha-treated hepatocytes was inhibited by leptomycin B, a blocker of CRM1 activity. Hepatic cells expressing the non-phosphorylatable C/EBPbeta alanine mutant were refractory to the inhibitory effects of TNF-alpha on albumin transcription since the mutant remained localized to the nucleus. Treatment of TNF-alpha mice with antioxidants or NOS inhibitors prevented phosphorylation of C/EBPbeta on Ser239 and its nuclear export, and rescued the abnormal albumin gene expression." @default.
• W2050389359 created "2016-06-24" @default.
• W2050389359 creator A5010612497 @default.
• W2050389359 creator A5023986637 @default.
• W2050389359 creator A5044997095 @default.
• W2050389359 creator A5054228197 @default.
• W2050389359 creator A5079723309 @default.
• W2050389359 date "2001-12-03" @default.
• W2050389359 modified "2023-10-18" @default.
• W2050389359 title "Nuclear export of phosphorylated C/EBPbeta mediates the inhibition of albumin expression by TNF-alpha" @default.
• W2050389359 cites W131517112 @default.
• W2050389359 cites W1506034405 @default.
• W2050389359 cites W1528493806 @default.
• W2050389359 cites W1563015642 @default.
• W2050389359 cites W1649504096 @default.
• W2050389359 cites W1773023954 @default.
• W2050389359 cites W179818011 @default.
• W2050389359 cites W1917885463 @default.
• W2050389359 cites W1965796676 @default.
• W2050389359 cites W1966986019 @default.
• W2050389359 cites W1975045802 @default.
• W2050389359 cites W1980142304 @default.
• W2050389359 cites W1992741759 @default.
• W2050389359 cites W2000644415 @default.
• W2050389359 cites W2001462532 @default.
• W2050389359 cites W2002580210 @default.
• W2050389359 cites W2004343006 @default.
• W2050389359 cites W2005994488 @default.
• W2050389359 cites W2008732319 @default.
• W2050389359 cites W2010042337 @default.
• W2050389359 cites W2010469212 @default.
• W2050389359 cites W2012255113 @default.
• W2050389359 cites W2012500579 @default.
• W2050389359 cites W2013114215 @default.
• W2050389359 cites W2016153572 @default.
• W2050389359 cites W2019894624 @default.
• W2050389359 cites W2022699060 @default.
• W2050389359 cites W2023386466 @default.
• W2050389359 cites W2024897106 @default.
• W2050389359 cites W2026257117 @default.
• W2050389359 cites W2026591908 @default.
• W2050389359 cites W2028355250 @default.
• W2050389359 cites W2034200840 @default.
• W2050389359 cites W2038256325 @default.
• W2050389359 cites W2047185571 @default.
• W2050389359 cites W2055209830 @default.
• W2050389359 cites W2056851249 @default.
• W2050389359 cites W2057093252 @default.
• W2050389359 cites W2062384458 @default.
• W2050389359 cites W2063859567 @default.
• W2050389359 cites W2066215499 @default.
• W2050389359 cites W2067623537 @default.
• W2050389359 cites W2069333165 @default.
• W2050389359 cites W2078853769 @default.
• W2050389359 cites W2084122627 @default.
• W2050389359 cites W2086107460 @default.
• W2050389359 cites W2088137004 @default.
• W2050389359 cites W2088696175 @default.
• W2050389359 cites W2107366065 @default.
• W2050389359 cites W2119577005 @default.
• W2050389359 cites W2122462682 @default.
• W2050389359 cites W2126093778 @default.
• W2050389359 cites W2126342903 @default.
• W2050389359 cites W2126540916 @default.
• W2050389359 cites W2129274801 @default.
• W2050389359 cites W2129889907 @default.
• W2050389359 cites W2142372451 @default.
• W2050389359 cites W2143262193 @default.
• W2050389359 cites W2151298994 @default.
• W2050389359 cites W2166788322 @default.
• W2050389359 cites W2170005346 @default.
• W2050389359 cites W2241851274 @default.
• W2050389359 cites W2269438046 @default.
• W2050389359 cites W2309989915 @default.
• W2050389359 cites W2323870293 @default.
• W2050389359 cites W2340280382 @default.
• W2050389359 cites W2403343829 @default.
• W2050389359 cites W321874077 @default.
• W2050389359 cites W4253590391 @default.
• W2050389359 cites W96614748 @default.
• W2050389359 cites W97264933 @default.
• W2050389359 doi "https://doi.org/10.1093/emboj/20.23.6712" @default.
• W2050389359 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/125761" @default.
• W2050389359 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11726507" @default.
• W2050389359 hasPublicationYear "2001" @default.
• W2050389359 type Work @default.
• W2050389359 sameAs 2050389359 @default.
• W2050389359 citedByCount "95" @default.
• W2050389359 countsByYear W20503893592012 @default.
• W2050389359 countsByYear W20503893592013 @default.
• W2050389359 countsByYear W20503893592014 @default.
• W2050389359 countsByYear W20503893592015 @default.
• W2050389359 countsByYear W20503893592016 @default.
• W2050389359 countsByYear W20503893592017 @default.
• W2050389359 countsByYear W20503893592019 @default.
• W2050389359 countsByYear W20503893592020 @default.
• W2050389359 countsByYear W20503893592021 @default.
• W2050389359 countsByYear W20503893592022 @default.

• next