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- W2050392234 abstract "The applicability of a polymer-drug interacted system in the physicochemical design of pharmaceutical dosage forms has been investigated. Salts of poly(methyl vinyl ether/maleic anhydride) and methapyrilene base were prepared. In vitro release patterns were determined by an equilibrium dialysis procedure. Dialytic release rates of the polymer-drug salt in solution demonstrated no appreciable difference in drug availability with respect to the free drug or its hydrochloride salt. In vitro dissolution rates of the polymer-drug salt in solid form showed similar results. Polymer-drug salts formed with the 1,12-dihydroxyoctadecane hemi-ester of poly-(methyl vinyl ether/maleic anhydride) exhibited prolongation of the release of the drug from granular and tableted forms in vitro." @default.
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- W2050392234 date "1968-09-01" @default.
- W2050392234 modified "2023-10-18" @default.
- W2050392234 title "Polymer–Drug Interacted Systems in the Physicochemical Design of Pharmaceutical Dosage Forms I" @default.
- W2050392234 cites W2166585971 @default.
- W2050392234 doi "https://doi.org/10.1002/jps.2600570927" @default.
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