FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050393710> ?p ?o ?g. }

• W2050393710 endingPage "867" @default.
• W2050393710 startingPage "860" @default.
• W2050393710 abstract "AK-5, a rat histiocytoma, is rejected in about 70% of the syngeneic animals when injected subcutaneously. The sera from the tumor rejecting animals possess a potent factor, referred to as serum factor (SF) that induces apoptosis in AK-5 tumor cells. In the present study, we show that treatment with SF or JAK/STAT inhibitors AG490 and Piceatannol induces apoptosis to a similar extent in BC-8 (a single cell clone of AK-5) cells. Our results demonstrate downregulation of a transcription factor, STAT3, as a critical regulator of SF-induced apoptosis in BC-8 cells. SF treatment enhanced the activity of NFkappaB, another transcription factor that regulates both pro- and antiapoptotic genes. The enhanced NFkappaB activity resulted in the elevation of TRAIL and its receptor DR4, both known to induce apoptosis. Activation of death receptors in turn enhances caspase-8 activity and stimulates the downstream pathways regulating BC-8 cell apoptosis. SF induced apoptosis in BC-8 cells mediated through downregulation of STAT3 and elevated NFkappaB activity is abrogated by treatment with MAPK inhibitors-PD98059 and SB203580. Our studies therefore indicate that modulation of MAPK activity plays a central role in SF-induced death signaling pathways in BC-8 cells." @default.
• W2050393710 created "2016-06-24" @default.
• W2050393710 creator A5042516678 @default.
• W2050393710 creator A5054913703 @default.
• W2050393710 creator A5071496681 @default.
• W2050393710 creator A5073242059 @default.
• W2050393710 creator A5084036733 @default.
• W2050393710 creator A5091776365 @default.
• W2050393710 date "2005-10-01" @default.
• W2050393710 modified "2023-09-26" @default.
• W2050393710 title "Role of STAT3 and NFκB signaling in the serum factor-induced apoptosis in AK-5 cells" @default.
• W2050393710 cites W1498787975 @default.
• W2050393710 cites W1507810589 @default.
• W2050393710 cites W1666352640 @default.
• W2050393710 cites W1796351973 @default.
• W2050393710 cites W1965398762 @default.
• W2050393710 cites W1968427910 @default.
• W2050393710 cites W1971715709 @default.
• W2050393710 cites W1972366604 @default.
• W2050393710 cites W1972987115 @default.
• W2050393710 cites W1976385326 @default.
• W2050393710 cites W1976903160 @default.
• W2050393710 cites W1984583623 @default.
• W2050393710 cites W1991429239 @default.
• W2050393710 cites W2016116775 @default.
• W2050393710 cites W2024282024 @default.
• W2050393710 cites W2041187882 @default.
• W2050393710 cites W2043803403 @default.
• W2050393710 cites W2055875066 @default.
• W2050393710 cites W2065349428 @default.
• W2050393710 cites W2067626539 @default.
• W2050393710 cites W2068502127 @default.
• W2050393710 cites W2069035291 @default.
• W2050393710 cites W2074356752 @default.
• W2050393710 cites W2083924342 @default.
• W2050393710 cites W2090628646 @default.
• W2050393710 cites W2106877484 @default.
• W2050393710 cites W2115798976 @default.
• W2050393710 cites W2118310862 @default.
• W2050393710 cites W2132249537 @default.
• W2050393710 cites W2134668672 @default.
• W2050393710 cites W2140490890 @default.
• W2050393710 cites W2142332666 @default.
• W2050393710 cites W2142848667 @default.
• W2050393710 cites W2150500559 @default.
• W2050393710 cites W2157942810 @default.
• W2050393710 cites W2166781237 @default.
• W2050393710 cites W2221359356 @default.
• W2050393710 cites W2321222503 @default.
• W2050393710 cites W2323400003 @default.
• W2050393710 cites W2408590861 @default.
• W2050393710 doi "https://doi.org/10.1016/j.bbrc.2005.08.185" @default.
• W2050393710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16153599" @default.
• W2050393710 hasPublicationYear "2005" @default.
• W2050393710 type Work @default.
• W2050393710 sameAs 2050393710 @default.
• W2050393710 citedByCount "7" @default.
• W2050393710 countsByYear W20503937102012 @default.
• W2050393710 crossrefType "journal-article" @default.
• W2050393710 hasAuthorship W2050393710A5042516678 @default.
• W2050393710 hasAuthorship W2050393710A5054913703 @default.
• W2050393710 hasAuthorship W2050393710A5071496681 @default.
• W2050393710 hasAuthorship W2050393710A5073242059 @default.
• W2050393710 hasAuthorship W2050393710A5084036733 @default.
• W2050393710 hasAuthorship W2050393710A5091776365 @default.
• W2050393710 hasConcept C104317684 @default.
• W2050393710 hasConcept C127561419 @default.
• W2050393710 hasConcept C153911025 @default.
• W2050393710 hasConcept C185592680 @default.
• W2050393710 hasConcept C190283241 @default.
• W2050393710 hasConcept C2778923194 @default.
• W2050393710 hasConcept C31573885 @default.
• W2050393710 hasConcept C502942594 @default.
• W2050393710 hasConcept C55493867 @default.
• W2050393710 hasConcept C57074206 @default.
• W2050393710 hasConcept C62478195 @default.
• W2050393710 hasConcept C6929976 @default.
• W2050393710 hasConcept C86339819 @default.
• W2050393710 hasConcept C86803240 @default.
• W2050393710 hasConcept C95444343 @default.
• W2050393710 hasConceptScore W2050393710C104317684 @default.
• W2050393710 hasConceptScore W2050393710C127561419 @default.
• W2050393710 hasConceptScore W2050393710C153911025 @default.
• W2050393710 hasConceptScore W2050393710C185592680 @default.
• W2050393710 hasConceptScore W2050393710C190283241 @default.
• W2050393710 hasConceptScore W2050393710C2778923194 @default.
• W2050393710 hasConceptScore W2050393710C31573885 @default.
• W2050393710 hasConceptScore W2050393710C502942594 @default.
• W2050393710 hasConceptScore W2050393710C55493867 @default.
• W2050393710 hasConceptScore W2050393710C57074206 @default.
• W2050393710 hasConceptScore W2050393710C62478195 @default.
• W2050393710 hasConceptScore W2050393710C6929976 @default.
• W2050393710 hasConceptScore W2050393710C86339819 @default.
• W2050393710 hasConceptScore W2050393710C86803240 @default.
• W2050393710 hasConceptScore W2050393710C95444343 @default.
• W2050393710 hasIssue "3" @default.
• W2050393710 hasLocation W20503937101 @default.
• W2050393710 hasLocation W20503937102 @default.

• next