FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050413914> ?p ?o ?g. }

• W2050413914 endingPage "484" @default.
• W2050413914 startingPage "484" @default.
• W2050413914 abstract "Multiple endocrine neoplasia type 1 (MEN1) consists of benign, and sometimes malignant, tumors (often multiple in a tissue) of the parathyroids, enteropancreatic neuroendocrine system, anterior pituitary, and other tissues.Skin angiofibromas and skin collagenomas are common. Typically, MEN1 tumors begin two decades earlier than sporadic tumors. Because of tumor multiplicity and the tendency for postoperative tumor recurrence, specialized methods have been developed for preoperative and intraoperative localization of many MEN1-associated tumors. The MEN1 gene was recently isolated by positional cloning.This strategy progressively narrows the size of the candidate MEN1 gene interval on the chromosome and then finds and tests many or, if needed, all genes within that interval. The MEN1 gene was finally identified because it was the one gene that contained mutations in most DNAs from a test panel of MEN1 cases. It has been suggested that MEN1, like many hereditary cancer syndromes, is caused by mutation in a tumor suppressor gene that contributes to neoplasia when both gene copies in a tumor precursor cell have been sequentially inactivated (“two-hit” oncogenesis mechanism). Germline MEN1 mutations were found in most families with MEN1 and in most cases of sporadic MEN1. In addition, the MEN1 gene was the gene most likely to show acquired mutation in several sporadic or nonhereditary tumors-parathyroid adenomas, gastrinomas, insulinomas, and bronchial carcinoids. Most germline or acquired MEN1 mutations predicted truncation (and thus likely inactivation) of the encoded protein, supporting expectations for the “first hit” to a tumor suppressor gene. Testing for MEN1 germline mutation is possible in a research setting. Candidates for MEN1 mutation testing include patients with MEN1 or its phenocopies and first-degree relatives of persons with MEN1." @default.
• W2050413914 created "2016-06-24" @default.
• W2050413914 creator A5052849207 @default.
• W2050413914 date "1998-09-15" @default.
• W2050413914 modified "2023-10-18" @default.
• W2050413914 title "Multiple Endocrine Neoplasia Type 1: Clinical and Genetic Topics" @default.
• W2050413914 cites W1499100567 @default.
• W2050413914 cites W1503554112 @default.
• W2050413914 cites W1535587358 @default.
• W2050413914 cites W1570164955 @default.
• W2050413914 cites W1573082990 @default.
• W2050413914 cites W1836699425 @default.
• W2050413914 cites W1925825565 @default.
• W2050413914 cites W1972584870 @default.
• W2050413914 cites W1974095890 @default.
• W2050413914 cites W1976870937 @default.
• W2050413914 cites W1990137877 @default.
• W2050413914 cites W1991062093 @default.
• W2050413914 cites W2003835377 @default.
• W2050413914 cites W2011010364 @default.
• W2050413914 cites W2011187030 @default.
• W2050413914 cites W2012589790 @default.
• W2050413914 cites W2017726138 @default.
• W2050413914 cites W2019769423 @default.
• W2050413914 cites W2022768063 @default.
• W2050413914 cites W2023367466 @default.
• W2050413914 cites W2030014588 @default.
• W2050413914 cites W2036212440 @default.
• W2050413914 cites W2037473917 @default.
• W2050413914 cites W2039694425 @default.
• W2050413914 cites W2039842131 @default.
• W2050413914 cites W2043087065 @default.
• W2050413914 cites W2044067295 @default.
• W2050413914 cites W2051264041 @default.
• W2050413914 cites W2056830288 @default.
• W2050413914 cites W2063137811 @default.
• W2050413914 cites W2071126398 @default.
• W2050413914 cites W2075962844 @default.
• W2050413914 cites W2077858999 @default.
• W2050413914 cites W2080190788 @default.
• W2050413914 cites W2083678197 @default.
• W2050413914 cites W2087451891 @default.
• W2050413914 cites W2089221493 @default.
• W2050413914 cites W2089779180 @default.
• W2050413914 cites W2090343636 @default.
• W2050413914 cites W2093684416 @default.
• W2050413914 cites W2104819108 @default.
• W2050413914 cites W2109847775 @default.
• W2050413914 cites W2114546531 @default.
• W2050413914 cites W2114789973 @default.
• W2050413914 cites W2116702160 @default.
• W2050413914 cites W2119481249 @default.
• W2050413914 cites W2127389995 @default.
• W2050413914 cites W2133824926 @default.
• W2050413914 cites W2138597212 @default.
• W2050413914 cites W2139589029 @default.
• W2050413914 cites W2157212789 @default.
• W2050413914 cites W2160983559 @default.
• W2050413914 cites W2162942974 @default.
• W2050413914 cites W2163231764 @default.
• W2050413914 cites W2317885408 @default.
• W2050413914 cites W2336883772 @default.
• W2050413914 cites W2337904583 @default.
• W2050413914 cites W2341242206 @default.
• W2050413914 doi "https://doi.org/10.7326/0003-4819-129-6-199809150-00011" @default.
• W2050413914 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9735087" @default.
• W2050413914 hasPublicationYear "1998" @default.
• W2050413914 type Work @default.
• W2050413914 sameAs 2050413914 @default.
• W2050413914 citedByCount "343" @default.
• W2050413914 countsByYear W20504139142012 @default.
• W2050413914 countsByYear W20504139142013 @default.
• W2050413914 countsByYear W20504139142014 @default.
• W2050413914 countsByYear W20504139142015 @default.
• W2050413914 countsByYear W20504139142016 @default.
• W2050413914 countsByYear W20504139142017 @default.
• W2050413914 countsByYear W20504139142018 @default.
• W2050413914 countsByYear W20504139142019 @default.
• W2050413914 countsByYear W20504139142020 @default.
• W2050413914 countsByYear W20504139142021 @default.
• W2050413914 countsByYear W20504139142022 @default.
• W2050413914 countsByYear W20504139142023 @default.
• W2050413914 crossrefType "journal-article" @default.
• W2050413914 hasAuthorship W2050413914A5052849207 @default.
• W2050413914 hasBestOaLocation W20504139141 @default.
• W2050413914 hasConcept C104317684 @default.
• W2050413914 hasConcept C109825262 @default.
• W2050413914 hasConcept C13514818 @default.
• W2050413914 hasConcept C2778264664 @default.
• W2050413914 hasConcept C2779469564 @default.
• W2050413914 hasConcept C2780103800 @default.
• W2050413914 hasConcept C3020804800 @default.
• W2050413914 hasConcept C501734568 @default.
• W2050413914 hasConcept C502942594 @default.
• W2050413914 hasConcept C54355233 @default.
• W2050413914 hasConcept C555283112 @default.
• W2050413914 hasConcept C71924100 @default.
• W2050413914 hasConcept C84597430 @default.

• next