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- W2050417299 abstract "Product performance test data are presented on Glycopyrrolate (GP), a LAMA, and Formoterol Fumarate (FF), a LABA, and their combination in Pearl’s HFA MDI format (GP MDI, FF MDI, and GP/FF combination MDI). GP and FF MDIs consistently deliver 18 and 2.4 µg GP and FF per actuation, respectively, with over 50% of the delivered dose in a particle size range suitable for uniform deposition in human airways. Their aerodynamic particle size distributions show excellent long term stability when stored at refrigerated (2-8°C), room temperature (25°C/60% RH) or stressed (40°C/75% RH) conditions. The delivered doses and aerosol properties of GP MDIs remain unchanged upon repeat thermal excursions between -5°C and 40°C for several weeks, demonstrating the robustness of Pearl’s novel HFA MDI suspensions. GP/FF MDIs also show excellent stability without any physical or chemical interaction between the two actives under a broad range of test conditions. The overall performance attributes for the two drugs in GP/FF MDI combination remain unchanged from the monotherapy GP and FF MDIs." @default.
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- W2050417299 date "2010-05-01" @default.
- W2050417299 modified "2023-09-26" @default.
- W2050417299 title "Glycopyrrolate And Formoterol Fumarate Monotherapy And Combination Metered Dose Inhalers With High Dose Uniformity And Stable Aerosol Properties" @default.
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- W2050417299 doi "https://doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a4452" @default.
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