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• W2050420102 abstract "20α-Hydroxysteroid dehydrogenase (20α-OHD) activity can be observed in the adrenal cortex of the young virgin female mouse using a histochemical staining procedure with blue tetrazolium (BT) which corresponds in distribution to the adrenal X-zone. The occurrence of both the 20α-OHD activity and the BT staining cells have been compared with changes in the X-zone after hormonal manipulation. The enzyme activity and BT staining cells can be induced in the male and female adrenal at age 8 days by estrogen administration. Normally the enzyme activity cannot be observed in the male adrenal, and not until the age of 12 days in the female adrenal. Treatment of both the male and the female with testosterone or progesterone causes regression of the X-zone and in the female there is a loss both of BT staining (qualitative) and of 20α-OHD enzyme activity, as well. The adrenal X-zone of the female mouse, which heretofore has been characterized only on the basis of morphology, can now be assessed by a biochemical parameter, the presence of 20α-OHD activity, an enzyme affected by sex steroid administration." @default.
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• W2050420102 date "1980-01-01" @default.
• W2050420102 modified "2023-10-18" @default.
• W2050420102 title "20α-Hydroxysteroid dehydrogenase activity and the x-zone of the female mouse adrenal" @default.
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• W2050420102 doi "https://doi.org/10.1016/0022-4731(80)90109-0" @default.
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