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• W2050422906 endingPage "329" @default.
• W2050422906 startingPage "322" @default.
• W2050422906 abstract "TMC125 is a nonnucleoside reverse transcriptase inhibitor (NNRTI) with potent in vitro activity against wild–type and NNRTI‐resistant HIV‐1. TMC125 is an inducer of CYP3A and an inhibitor of CYP2C. This trial evaluated the effect of TMC125 on the pharmacokinetics and pharmacodynamics of methadone. In an open‐label, add‐on, 1‐way interaction trial, 16 male HIV‐negative volunteers on stable methadone maintenance therapy received 100 mg TMC125 bid for 14 days. Plasma concentrations and pharmacokinetic parameters of R‐ and S‐methadone isomers were determined on days −1, 7, and 14 and of TMC125 on days 7 and 14. Safety and tolerability were assessed. The LSmeans ratios (90% confidence interval) for AUC 24h , C max , and C min of the pharmacologically active R‐methadone were 1.08 (1.02–1.13), 1.03 (0.97–1.09), and 1.12 (1.05–1.19), respectively, on day 7 and 1.06 (0.99–1.13), 1.02 (0.96–1.09), and 1.10 (1.02–1.19), respectively, on day 14 compared with methadone alone. No withdrawal symptoms were observed; dose adjustment of methadone was not required. The concomitant administration of TMC125 and methadone was generally safe and well tolerated. TMC125 has no clinically relevant effect on the pharmacokinetics or pharmacodynamics of methadone. No dose adjustment for methadone is anticipated when coadministered with TMC125." @default.
• W2050422906 created "2016-06-24" @default.
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• W2050422906 date "2008-03-01" @default.
• W2050422906 modified "2023-10-17" @default.
• W2050422906 title "Pharmacokinetic and Pharmacodynamic Study of the Concomitant Administration of Methadone and TMC125 in HIV-Negative Volunteers" @default.
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• W2050422906 doi "https://doi.org/10.1177/0091270007310387" @default.
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