FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050427247> ?p ?o ?g. }

• W2050427247 endingPage "4003" @default.
• W2050427247 startingPage "3998" @default.
• W2050427247 abstract "Synaptotagmin-1, the canonical isoform of the synaptotagmin family, is a Ca(2+) sensor for fast synchronous neurotransmitter release in forebrain neurons and chromaffin cells. Even though deletion of synaptotagmin-1 abolishes fast exocytosis in chromaffin cells, it reduces overall secretion by only 20% because of the persistence of slow exocytosis. Therefore, another Ca(2+) sensor dominates release in these cells. Synaptotagmin-7 has a higher Ca(2+) affinity and slower binding kinetics than synaptotagmin-1, matching the proposed properties for the second, slower Ca(2+) sensor. Here, we examined Ca(2+)-triggered exocytosis in chromaffin cells from KO mice lacking synaptotagmin-7, and from knockin mice containing normal levels of a mutant synaptotagmin-7 whose C(2)B domain does not bind Ca(2+). In both types of mutant chromaffin cells, Ca(2+)-triggered exocytosis was decreased dramatically. Moreover, in chromaffin cells lacking both synaptotagmin-1 and -7, only a very slow release component, accounting for approximately 30% of WT exocytosis, persisted. These data establish synaptotagmin-7 as a major Ca(2+) sensor for exocytosis in chromaffin cells, which, together with synaptotagmin-1, mediates almost all of the Ca(2+) triggering of exocytosis in these cells, a surprising result, considering the lack of a role of synaptotagmin-7 in synaptic vesicle exocytosis." @default.
• W2050427247 created "2016-06-24" @default.
• W2050427247 creator A5033310893 @default.
• W2050427247 creator A5034099827 @default.
• W2050427247 creator A5034269214 @default.
• W2050427247 creator A5050194393 @default.
• W2050427247 creator A5061921730 @default.
• W2050427247 date "2008-03-11" @default.
• W2050427247 modified "2023-09-27" @default.
• W2050427247 title "Synaptotagmin-1 and -7 are functionally overlapping Ca ²⁺ sensors for exocytosis in adrenal chromaffin cells" @default.
• W2050427247 cites W1512666490 @default.
• W2050427247 cites W1880170891 @default.
• W2050427247 cites W1963551844 @default.
• W2050427247 cites W1966803885 @default.
• W2050427247 cites W1972055048 @default.
• W2050427247 cites W1980682773 @default.
• W2050427247 cites W1981668412 @default.
• W2050427247 cites W1990653906 @default.
• W2050427247 cites W1990976146 @default.
• W2050427247 cites W1992163176 @default.
• W2050427247 cites W1994265121 @default.
• W2050427247 cites W1996162595 @default.
• W2050427247 cites W2009210403 @default.
• W2050427247 cites W2010315760 @default.
• W2050427247 cites W2016698582 @default.
• W2050427247 cites W2018757497 @default.
• W2050427247 cites W2037168572 @default.
• W2050427247 cites W2038870054 @default.
• W2050427247 cites W2043875151 @default.
• W2050427247 cites W2063268584 @default.
• W2050427247 cites W2072696058 @default.
• W2050427247 cites W2072730361 @default.
• W2050427247 cites W2073850595 @default.
• W2050427247 cites W2076682533 @default.
• W2050427247 cites W2078686355 @default.
• W2050427247 cites W2080932989 @default.
• W2050427247 cites W2083133268 @default.
• W2050427247 cites W2094059060 @default.
• W2050427247 cites W2095144685 @default.
• W2050427247 cites W2110749794 @default.
• W2050427247 cites W2123355036 @default.
• W2050427247 cites W2132877537 @default.
• W2050427247 cites W2137163623 @default.
• W2050427247 cites W2153860862 @default.
• W2050427247 cites W2165056042 @default.
• W2050427247 cites W2165302477 @default.
• W2050427247 cites W2168315683 @default.
• W2050427247 cites W2170282177 @default.
• W2050427247 cites W2172248769 @default.
• W2050427247 doi "https://doi.org/10.1073/pnas.0712373105" @default.
• W2050427247 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2268838" @default.
• W2050427247 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18308932" @default.
• W2050427247 hasPublicationYear "2008" @default.
• W2050427247 type Work @default.
• W2050427247 sameAs 2050427247 @default.
• W2050427247 citedByCount "170" @default.
• W2050427247 countsByYear W20504272472012 @default.
• W2050427247 countsByYear W20504272472013 @default.
• W2050427247 countsByYear W20504272472014 @default.
• W2050427247 countsByYear W20504272472015 @default.
• W2050427247 countsByYear W20504272472016 @default.
• W2050427247 countsByYear W20504272472017 @default.
• W2050427247 countsByYear W20504272472018 @default.
• W2050427247 countsByYear W20504272472019 @default.
• W2050427247 countsByYear W20504272472020 @default.
• W2050427247 countsByYear W20504272472021 @default.
• W2050427247 countsByYear W20504272472022 @default.
• W2050427247 crossrefType "journal-article" @default.
• W2050427247 hasAuthorship W2050427247A5033310893 @default.
• W2050427247 hasAuthorship W2050427247A5034099827 @default.
• W2050427247 hasAuthorship W2050427247A5034269214 @default.
• W2050427247 hasAuthorship W2050427247A5050194393 @default.
• W2050427247 hasAuthorship W2050427247A5061921730 @default.
• W2050427247 hasBestOaLocation W20504272471 @default.
• W2050427247 hasConcept C130316041 @default.
• W2050427247 hasConcept C134018914 @default.
• W2050427247 hasConcept C148785051 @default.
• W2050427247 hasConcept C175969161 @default.
• W2050427247 hasConcept C185592680 @default.
• W2050427247 hasConcept C2775894120 @default.
• W2050427247 hasConcept C2777597313 @default.
• W2050427247 hasConcept C2778256703 @default.
• W2050427247 hasConcept C2780910648 @default.
• W2050427247 hasConcept C2909695770 @default.
• W2050427247 hasConcept C41625074 @default.
• W2050427247 hasConcept C49039625 @default.
• W2050427247 hasConcept C53728453 @default.
• W2050427247 hasConcept C55493867 @default.
• W2050427247 hasConcept C86473631 @default.
• W2050427247 hasConcept C86803240 @default.
• W2050427247 hasConcept C95444343 @default.
• W2050427247 hasConceptScore W2050427247C130316041 @default.
• W2050427247 hasConceptScore W2050427247C134018914 @default.
• W2050427247 hasConceptScore W2050427247C148785051 @default.
• W2050427247 hasConceptScore W2050427247C175969161 @default.
• W2050427247 hasConceptScore W2050427247C185592680 @default.
• W2050427247 hasConceptScore W2050427247C2775894120 @default.
• W2050427247 hasConceptScore W2050427247C2777597313 @default.

• next