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• W2050433368 abstract "Bone morphogenetic proteins (BMPs) initiate, promote, and maintain chondrogenesis and osteogenesis. We hypothesize that BMP-2 induces an osteogenic, and BMP-7 a chondrogenic phenotype in adipose tissue-derived mesenchymal stem cells (AT-MSCs). We compared the effects of a short 15 min BMP-2 or BMP-7 (10 ng/ml) treatment on osteogenic and chondrogenic differentiation of AT-MSCs. Gene expression was studied 4 and 14 days after BMP-treatment. At day 4 BMP-2, but not BMP-7, stimulated runx-2 and osteopontin gene expression, and at day 14 BMP-7 down-regulated expression of these genes. At day 4 BMP-2 and BMP-7 stimulated biglycan gene expression, which was down-regulated by BMP-7 at day 14. BMP-7 stimulated aggrecan gene expression at day 14. Our data indicate that BMP-2 treatment for 15 min induces osteogenic differentiation, whereas BMP-7 stimulates a chondrogenic phenotype of AT-MSCs. Therefore, AT-MSCs triggered for only 15 min with BMP-2 or BMP-7 provide a feasible tool for bone and cartilage tissue engineering." @default.
• W2050433368 created "2016-06-24" @default.
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• W2050433368 date "2006-04-01" @default.
• W2050433368 modified "2023-10-11" @default.
• W2050433368 title "Osteogenesis versus chondrogenesis by BMP-2 and BMP-7 in adipose stem cells" @default.
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• W2050433368 doi "https://doi.org/10.1016/j.bbrc.2006.02.052" @default.
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