Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050438861> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2050438861 endingPage "228" @default.
- W2050438861 startingPage "221" @default.
- W2050438861 abstract "Abstract N ‐Formyl peptides are cleavage products of bacterial and mitochondrial proteins that have pro‐inflammatory activities and play an important role in antibacterial host defence. FcγRI is a receptor for the Fc portion of immunoglobulin G expressed in monocytes that mediates cytotoxicity and is upregulated by interferon‐γ (IFN‐γ) and interleukin‐10 (IL‐10). In this report, we demonstrate that N ‐formyl‐methionyl‐leucyl‐phenylalanine (FMLP) downregulates the expression of FcγRI in IFN‐γ‐treated monocytes, but not in IL‐10‐treated monocytes. We determine that supernatants obtained from monocytes treated with IFN‐γ and then exposed to FMLP induce the downregulation of FcγRI in naïve monocytes. This effect is abrogated by the protease inhibitors phenylmethylsulphonyl fluoride and phosphoramidon, which inhibit serine and metalloproteases, respectively. Supernatants from FMLP‐treated neutrophils also induce the downregulation of FcγRI, when added to naïve monocytes. Similar observations were obtained in vivo in a mouse model of chronic inflammation. In vivo , FMLP also downregulates the expression of FcγRs in IFN‐γ‐activated macrophages. Our results support the existence of a new mechanism through which FMLP could modulate the activity of monocytes/macrophages during bacterial infections." @default.
- W2050438861 created "2016-06-24" @default.
- W2050438861 creator A5022419643 @default.
- W2050438861 creator A5047196610 @default.
- W2050438861 creator A5058854988 @default.
- W2050438861 creator A5065910864 @default.
- W2050438861 creator A5081767592 @default.
- W2050438861 creator A5089376156 @default.
- W2050438861 date "2003-03-01" @default.
- W2050438861 modified "2023-10-14" @default.
- W2050438861 title "The Formyl Peptide N-Formyl-methionyl-leucyl-phenylalanine Downregulates the Expression of FcgammaRs in Interferon-gamma-Activated Monocytes/Macrophages In Vitro and In Vivo" @default.
- W2050438861 cites W1481714339 @default.
- W2050438861 cites W1531938298 @default.
- W2050438861 cites W1583083707 @default.
- W2050438861 cites W1780375984 @default.
- W2050438861 cites W1971347860 @default.
- W2050438861 cites W1977631644 @default.
- W2050438861 cites W1994805857 @default.
- W2050438861 cites W2000758020 @default.
- W2050438861 cites W2001286841 @default.
- W2050438861 cites W2018528500 @default.
- W2050438861 cites W2063631657 @default.
- W2050438861 cites W2091943511 @default.
- W2050438861 cites W2105360761 @default.
- W2050438861 cites W2106004630 @default.
- W2050438861 cites W2107674548 @default.
- W2050438861 cites W2117057528 @default.
- W2050438861 cites W2118687030 @default.
- W2050438861 cites W2124627840 @default.
- W2050438861 cites W2138387587 @default.
- W2050438861 cites W2154901790 @default.
- W2050438861 cites W2158763004 @default.
- W2050438861 cites W2168930459 @default.
- W2050438861 cites W2170332275 @default.
- W2050438861 cites W2182180814 @default.
- W2050438861 cites W2398896441 @default.
- W2050438861 cites W4313331468 @default.
- W2050438861 doi "https://doi.org/10.1046/j.1365-3083.2003.01219.x" @default.
- W2050438861 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12641650" @default.
- W2050438861 hasPublicationYear "2003" @default.
- W2050438861 type Work @default.
- W2050438861 sameAs 2050438861 @default.
- W2050438861 citedByCount "10" @default.
- W2050438861 countsByYear W20504388612016 @default.
- W2050438861 crossrefType "journal-article" @default.
- W2050438861 hasAuthorship W2050438861A5022419643 @default.
- W2050438861 hasAuthorship W2050438861A5047196610 @default.
- W2050438861 hasAuthorship W2050438861A5058854988 @default.
- W2050438861 hasAuthorship W2050438861A5065910864 @default.
- W2050438861 hasAuthorship W2050438861A5081767592 @default.
- W2050438861 hasAuthorship W2050438861A5089376156 @default.
- W2050438861 hasBestOaLocation W20504388611 @default.
- W2050438861 hasConcept C104317684 @default.
- W2050438861 hasConcept C127561419 @default.
- W2050438861 hasConcept C150903083 @default.
- W2050438861 hasConcept C153911025 @default.
- W2050438861 hasConcept C181199279 @default.
- W2050438861 hasConcept C185592680 @default.
- W2050438861 hasConcept C202751555 @default.
- W2050438861 hasConcept C207001950 @default.
- W2050438861 hasConcept C2776714187 @default.
- W2050438861 hasConcept C2777807008 @default.
- W2050438861 hasConcept C55493867 @default.
- W2050438861 hasConcept C86803240 @default.
- W2050438861 hasConceptScore W2050438861C104317684 @default.
- W2050438861 hasConceptScore W2050438861C127561419 @default.
- W2050438861 hasConceptScore W2050438861C150903083 @default.
- W2050438861 hasConceptScore W2050438861C153911025 @default.
- W2050438861 hasConceptScore W2050438861C181199279 @default.
- W2050438861 hasConceptScore W2050438861C185592680 @default.
- W2050438861 hasConceptScore W2050438861C202751555 @default.
- W2050438861 hasConceptScore W2050438861C207001950 @default.
- W2050438861 hasConceptScore W2050438861C2776714187 @default.
- W2050438861 hasConceptScore W2050438861C2777807008 @default.
- W2050438861 hasConceptScore W2050438861C55493867 @default.
- W2050438861 hasConceptScore W2050438861C86803240 @default.
- W2050438861 hasIssue "3" @default.
- W2050438861 hasLocation W20504388611 @default.
- W2050438861 hasLocation W20504388612 @default.
- W2050438861 hasOpenAccess W2050438861 @default.
- W2050438861 hasPrimaryLocation W20504388611 @default.
- W2050438861 hasRelatedWork W1566729005 @default.
- W2050438861 hasRelatedWork W1700716001 @default.
- W2050438861 hasRelatedWork W2013908504 @default.
- W2050438861 hasRelatedWork W2054843986 @default.
- W2050438861 hasRelatedWork W2116210813 @default.
- W2050438861 hasRelatedWork W2138350991 @default.
- W2050438861 hasRelatedWork W2409285845 @default.
- W2050438861 hasRelatedWork W2434195791 @default.
- W2050438861 hasRelatedWork W2440701365 @default.
- W2050438861 hasRelatedWork W3015376786 @default.
- W2050438861 hasVolume "57" @default.
- W2050438861 isParatext "false" @default.
- W2050438861 isRetracted "false" @default.
- W2050438861 magId "2050438861" @default.
- W2050438861 workType "article" @default.