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• W2050440015 abstract "Synovium is considered a candidate source of cells for cartilage tissue engineering. Compared with mesenchymal stem cells (MSCs) from other sources, synovium-derived stem cells (SDSCs) have a higher capacity for chondrogenic differentiation. Our objective was to define cocktails of growth factors that support the growth and chondrogenic differentiation of SDSCs in chemically defined medium. We established a fast and highly selective technique of negative isolation of SDSC populations. The individual and combined effects of three growth factors—transforming growth factor-β1 (TGF-β1), insulin-like growth factor I (IGF-I), and basic fibroblast growth factor (FGF-2)—were evaluated in serum-free pellet cultures of SDSCs for the chondrogenesis of SDSCs using histology, biochemical analysis, and real-time RT-PCR. In vitro studies identified TGF-β1 as the key factor for both the growth and chondrogenesis of SDSCs. The highest rates of SDSC growth were observed with the synergistic interaction of all three factors. With respect to chondrogenic differentiation of SDSCs, the interaction of TGF-β1 and IGF-I applied simultaneously was superior to the sequential application of these two factors or any other combination of growth factors studied. Based on these findings, we propose a two-step protocol for the derivation of chondrogenic SDSCs: a cocktail of TGF-β1, IGF-I, and FGF-2 is applied first to induce cell growth followed by a cocktail of TGF-β1 and IGF-I applied to induce chondrogenesis." @default.
• W2050440015 created "2016-06-24" @default.
• W2050440015 creator A5044928451 @default.
• W2050440015 creator A5062679781 @default.
• W2050440015 creator A5083771262 @default.
• W2050440015 date "2008-12-01" @default.
• W2050440015 modified "2023-10-18" @default.
• W2050440015 title "Synovium-derived stem cell-based chondrogenesis" @default.
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• W2050440015 doi "https://doi.org/10.1111/j.1432-0436.2008.00299.x" @default.
• W2050440015 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2772098" @default.
• W2050440015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18637024" @default.
• W2050440015 hasPublicationYear "2008" @default.
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