FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050451007> ?p ?o ?g. }

• W2050451007 endingPage "493" @default.
• W2050451007 startingPage "483" @default.
• W2050451007 abstract "Brain-derived neurotrophic factor has been shown to be neuroprotective in models of excitotoxicity, axotomy and cerebral ischemia. The present study evaluated the therapeutic potential of brain-derived neurotrophic factor following traumatic brain injury in the rat. Male Sprague-Dawley rats (N=99) were anesthetized and subjected to lateral fluid percussion brain injury of moderate severity (2.4-2.8 atm) or sham injury. Four hours after injury, the animals were reanesthetized, an indwelling, intraparenchymal cannula was implanted, and infusion of brain-derived neurotrophic factor or phosphate-buffered saline vehicle was initiated from a mini-osmotic pump and continued for two weeks. In Study 1 (N=48), vehicle or 12 microg/day of brain-derived neurotrophic factor was infused into the dorsal hippocampus. In Study 2 (N=51), vehicle or brain-derived neurotrophic factor at a high (12 microg/day) or low dose (1.2 microg/day) was infused into the injured parietal cortex. All animals were evaluated for neurological motor function at two days, one week and two weeks post-injury. Cognitive function (learning and memory) was assessed at two weeks post-injury using a Morris Water Maze. At two weeks post-injury, neuronal loss in the hippocampal CA3 and dentate hilus and in the injured cortex was evaluated. In Study 2, neuronal loss was also quantified in the thalamic medial geniculate nucleus. All of the above outcome measures demonstrated significant deleterious effects of brain injury (P<0.05 compared to sham). However, post-traumatic brain-derived neurotrophic factor infusion did not significantly affect neuromotor function, learning, memory or neuronal loss in the hippocampus, cortex or thalamus when compared to vehicle infusion in brain-injured animals, regardless of the infusion site or infusion dose (P>0.05 for each). In contrast to previous studies of axotomy, ischemia and excitotoxicity, our data indicate that brain-derived neurotrophic factor is not protective against behavioral or histological deficits caused by experimental traumatic brain injury using the delayed, post-traumatic infusion protocol examined in these studies." @default.
• W2050451007 created "2016-06-24" @default.
• W2050451007 creator A5010152737 @default.
• W2050451007 creator A5040229561 @default.
• W2050451007 creator A5061860555 @default.
• W2050451007 creator A5073052039 @default.
• W2050451007 date "2000-08-01" @default.
• W2050451007 modified "2023-10-16" @default.
• W2050451007 title "Brain-derived neurotrophic factor administration after traumatic brain injury in the rat does not protect against behavioral or histological deficits" @default.
• W2050451007 cites W1565095682 @default.
• W2050451007 cites W1575167357 @default.
• W2050451007 cites W1590012920 @default.
• W2050451007 cites W1600830780 @default.
• W2050451007 cites W1747922801 @default.
• W2050451007 cites W1871684389 @default.
• W2050451007 cites W1891880696 @default.
• W2050451007 cites W1934034828 @default.
• W2050451007 cites W1966311061 @default.
• W2050451007 cites W1967475748 @default.
• W2050451007 cites W1969408505 @default.
• W2050451007 cites W1971742587 @default.
• W2050451007 cites W1979305117 @default.
• W2050451007 cites W1979824327 @default.
• W2050451007 cites W1979986609 @default.
• W2050451007 cites W1983317203 @default.
• W2050451007 cites W1983490728 @default.
• W2050451007 cites W1984795811 @default.
• W2050451007 cites W1985815419 @default.
• W2050451007 cites W1986466078 @default.
• W2050451007 cites W1987904402 @default.
• W2050451007 cites W1988660081 @default.
• W2050451007 cites W1988791308 @default.
• W2050451007 cites W1990031445 @default.
• W2050451007 cites W1990383598 @default.
• W2050451007 cites W1990504758 @default.
• W2050451007 cites W1993870032 @default.
• W2050451007 cites W1999335813 @default.
• W2050451007 cites W2000612118 @default.
• W2050451007 cites W2002802904 @default.
• W2050451007 cites W2004469687 @default.
• W2050451007 cites W2006514144 @default.
• W2050451007 cites W2007897070 @default.
• W2050451007 cites W2011208889 @default.
• W2050451007 cites W2012825989 @default.
• W2050451007 cites W2013895271 @default.
• W2050451007 cites W2014567150 @default.
• W2050451007 cites W2017169966 @default.
• W2050451007 cites W2018524477 @default.
• W2050451007 cites W2021218882 @default.
• W2050451007 cites W2026847407 @default.
• W2050451007 cites W2027475151 @default.
• W2050451007 cites W2027988197 @default.
• W2050451007 cites W2028707709 @default.
• W2050451007 cites W2029247231 @default.
• W2050451007 cites W2033027472 @default.
• W2050451007 cites W2033333756 @default.
• W2050451007 cites W2033367566 @default.
• W2050451007 cites W2035565598 @default.
• W2050451007 cites W2036341167 @default.
• W2050451007 cites W2041391753 @default.
• W2050451007 cites W2045180058 @default.
• W2050451007 cites W2047075116 @default.
• W2050451007 cites W2048873465 @default.
• W2050451007 cites W2051600135 @default.
• W2050451007 cites W2051600991 @default.
• W2050451007 cites W2052566611 @default.
• W2050451007 cites W2054336759 @default.
• W2050451007 cites W2054595326 @default.
• W2050451007 cites W2056398740 @default.
• W2050451007 cites W2061790271 @default.
• W2050451007 cites W2063616597 @default.
• W2050451007 cites W2063964698 @default.
• W2050451007 cites W2065009470 @default.
• W2050451007 cites W2065544304 @default.
• W2050451007 cites W2069527370 @default.
• W2050451007 cites W2069533982 @default.
• W2050451007 cites W2071277983 @default.
• W2050451007 cites W2074595931 @default.
• W2050451007 cites W2077702812 @default.
• W2050451007 cites W2078320124 @default.
• W2050451007 cites W2091316910 @default.
• W2050451007 cites W2092324476 @default.
• W2050451007 cites W2099690691 @default.
• W2050451007 cites W2100665719 @default.
• W2050451007 cites W2102284349 @default.
• W2050451007 cites W2103884832 @default.
• W2050451007 cites W2113724937 @default.
• W2050451007 cites W2122127855 @default.
• W2050451007 cites W2127447774 @default.
• W2050451007 cites W2139075848 @default.
• W2050451007 cites W2145748909 @default.
• W2050451007 cites W2149533590 @default.
• W2050451007 cites W2157001082 @default.
• W2050451007 cites W2222580064 @default.
• W2050451007 cites W2313917204 @default.
• W2050451007 cites W2352727163 @default.
• W2050451007 cites W43432051 @default.
• W2050451007 doi "https://doi.org/10.1016/s0306-4522(00)00214-1" @default.

• next