FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050472011> ?p ?o ?g. }

• W2050472011 endingPage "2274" @default.
• W2050472011 startingPage "2271" @default.
• W2050472011 abstract "Cytotoxic T lymphocytes (CTL) kill target cells by perforin-mediated pore formation, induction of apoptosis by the Fas ligand, or both. It has been demonstrated that depolarized neurons can be induced to express major histocompatibility complex (MHC) class I antigens by interferon-gamma. Evidence for antigen-dependent CTL-mediated killing was obtained by transfecting neurons with MHC class I cDNA. The present study was designed to investigate the mechanisms of killing of cerebellar granule neurons depolarized by high K+ concentrations and thereby inducible for MHC class I antigen expression. We found that neurons express only low levels of Fas (APO-1/CD95) and are resistant to Fas ligand-mediated killing even when pretreated with cytokines. However, granules extracted from CTL as well as purified perforin induce almost complete lysis of neurons. These data suggest that CTL-mediated elimination of neurons involves the perforin, but not the Fas pathway of target cell killing." @default.
• W2050472011 created "2016-06-24" @default.
• W2050472011 creator A5011962897 @default.
• W2050472011 creator A5048039802 @default.
• W2050472011 creator A5059727262 @default.
• W2050472011 creator A5064346931 @default.
• W2050472011 creator A5073200002 @default.
• W2050472011 creator A5085253611 @default.
• W2050472011 date "1996-09-01" @default.
• W2050472011 modified "2023-10-17" @default.
• W2050472011 title "Neurons induced to express major histocompatibility complex class I antigen are killed via the perforin and not the Fas (APO-1/CD95) pathway" @default.
• W2050472011 cites W1981182552 @default.
• W2050472011 cites W1985754957 @default.
• W2050472011 cites W2010003461 @default.
• W2050472011 cites W2016575029 @default.
• W2050472011 cites W2039596527 @default.
• W2050472011 cites W2041478444 @default.
• W2050472011 cites W2056924500 @default.
• W2050472011 cites W2083363077 @default.
• W2050472011 cites W2084542841 @default.
• W2050472011 cites W2091720585 @default.
• W2050472011 cites W2092589738 @default.
• W2050472011 cites W2106724288 @default.
• W2050472011 cites W2108257172 @default.
• W2050472011 cites W2133287830 @default.
• W2050472011 cites W2152605676 @default.
• W2050472011 cites W2166487006 @default.
• W2050472011 cites W2409704727 @default.
• W2050472011 cites W252613826 @default.
• W2050472011 cites W4244374547 @default.
• W2050472011 doi "https://doi.org/10.1002/eji.1830260945" @default.
• W2050472011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8814277" @default.
• W2050472011 hasPublicationYear "1996" @default.
• W2050472011 type Work @default.
• W2050472011 sameAs 2050472011 @default.
• W2050472011 citedByCount "62" @default.
• W2050472011 countsByYear W20504720112013 @default.
• W2050472011 countsByYear W20504720112014 @default.
• W2050472011 countsByYear W20504720112015 @default.
• W2050472011 countsByYear W20504720112017 @default.
• W2050472011 countsByYear W20504720112019 @default.
• W2050472011 countsByYear W20504720112021 @default.
• W2050472011 countsByYear W20504720112022 @default.
• W2050472011 countsByYear W20504720112023 @default.
• W2050472011 crossrefType "journal-article" @default.
• W2050472011 hasAuthorship W2050472011A5011962897 @default.
• W2050472011 hasAuthorship W2050472011A5048039802 @default.
• W2050472011 hasAuthorship W2050472011A5059727262 @default.
• W2050472011 hasAuthorship W2050472011A5064346931 @default.
• W2050472011 hasAuthorship W2050472011A5073200002 @default.
• W2050472011 hasAuthorship W2050472011A5085253611 @default.
• W2050472011 hasConcept C147483822 @default.
• W2050472011 hasConcept C147969180 @default.
• W2050472011 hasConcept C153911025 @default.
• W2050472011 hasConcept C154317977 @default.
• W2050472011 hasConcept C167672396 @default.
• W2050472011 hasConcept C170627219 @default.
• W2050472011 hasConcept C190283241 @default.
• W2050472011 hasConcept C202751555 @default.
• W2050472011 hasConcept C203014093 @default.
• W2050472011 hasConcept C207936829 @default.
• W2050472011 hasConcept C2776062744 @default.
• W2050472011 hasConcept C3031857 @default.
• W2050472011 hasConcept C31573885 @default.
• W2050472011 hasConcept C55493867 @default.
• W2050472011 hasConcept C66008609 @default.
• W2050472011 hasConcept C86803240 @default.
• W2050472011 hasConcept C95444343 @default.
• W2050472011 hasConceptScore W2050472011C147483822 @default.
• W2050472011 hasConceptScore W2050472011C147969180 @default.
• W2050472011 hasConceptScore W2050472011C153911025 @default.
• W2050472011 hasConceptScore W2050472011C154317977 @default.
• W2050472011 hasConceptScore W2050472011C167672396 @default.
• W2050472011 hasConceptScore W2050472011C170627219 @default.
• W2050472011 hasConceptScore W2050472011C190283241 @default.
• W2050472011 hasConceptScore W2050472011C202751555 @default.
• W2050472011 hasConceptScore W2050472011C203014093 @default.
• W2050472011 hasConceptScore W2050472011C207936829 @default.
• W2050472011 hasConceptScore W2050472011C2776062744 @default.
• W2050472011 hasConceptScore W2050472011C3031857 @default.
• W2050472011 hasConceptScore W2050472011C31573885 @default.
• W2050472011 hasConceptScore W2050472011C55493867 @default.
• W2050472011 hasConceptScore W2050472011C66008609 @default.
• W2050472011 hasConceptScore W2050472011C86803240 @default.
• W2050472011 hasConceptScore W2050472011C95444343 @default.
• W2050472011 hasIssue "9" @default.
• W2050472011 hasLocation W20504720111 @default.
• W2050472011 hasLocation W20504720112 @default.
• W2050472011 hasOpenAccess W2050472011 @default.
• W2050472011 hasPrimaryLocation W20504720111 @default.
• W2050472011 hasRelatedWork W1581712504 @default.
• W2050472011 hasRelatedWork W1661600713 @default.
• W2050472011 hasRelatedWork W1675773181 @default.
• W2050472011 hasRelatedWork W1961486822 @default.
• W2050472011 hasRelatedWork W2020086511 @default.
• W2050472011 hasRelatedWork W2021419475 @default.
• W2050472011 hasRelatedWork W2032123081 @default.
• W2050472011 hasRelatedWork W2050472011 @default.

• next