Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050475053> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2050475053 endingPage "2720" @default.
- W2050475053 startingPage "2716" @default.
- W2050475053 abstract "The resurgence of tuberculosis (TB) and emergence of multidrug-resistant TB (MDR-TB) are significant obstacles to stop TB treatment. Capreomycin (CPM) is regarded as an ideal second-line treatment for TB as well as for MDR-TB. However, the inexorable emergence of capreomycin resistant TB cases accentuates the urgent need for more detailed characterization of CPM targets. Most of these are single gene mutation, such as those involved in the complex formation of ribosomal 30S initiation, inhibit protein synthesis, affect 50S ribosomal protein L10, control transcription and translation of operon rpIJL-rpoBC. A new paradigm integrating gene, small metabolites, protein and underlying signaling pathway to shed light on the physiology, pathogenesis, and network of pathogen response is emerging. This model holds great promise to unravel the intricacy of drug action. However, to our knowledge, no such work regarding Mycobacterium tuberculosis response to capreomycin exposure was ever reported. We employed the data mining to construct an interaction topology of M. tuberculosis genes response to capreomycin. Most valuable genes were summarized for further experimental validation based on this topology. Dampening the virulence factors and respiratory of M. tuberculosis might be the new targets of CPM beyond Rv1364c, pe_pgrs38, pe_pgrs51 which are the salient nodes of the network and represent most promising new capreomycin targets meriting further exploration. This work will facilitate further investigation of capreomycin targets against M. tuberculosis and be conducive to novel TB drug discovery. J. Cell. Biochem. 112: 2716–2720, 2011. © 2011 Wiley-Liss, Inc." @default.
- W2050475053 created "2016-06-24" @default.
- W2050475053 creator A5051405082 @default.
- W2050475053 creator A5063020503 @default.
- W2050475053 date "2011-09-19" @default.
- W2050475053 modified "2023-09-26" @default.
- W2050475053 title "The interaction topology of Mycobacterium tuberculosis genes response to capreomycin and novel clues for more drug targets" @default.
- W2050475053 cites W1513102582 @default.
- W2050475053 cites W1966811261 @default.
- W2050475053 cites W1967912835 @default.
- W2050475053 cites W1974402216 @default.
- W2050475053 cites W1999838562 @default.
- W2050475053 cites W2003810398 @default.
- W2050475053 cites W2004124455 @default.
- W2050475053 cites W2010184230 @default.
- W2050475053 cites W2010707723 @default.
- W2050475053 cites W2023664487 @default.
- W2050475053 cites W2042971327 @default.
- W2050475053 cites W2057713237 @default.
- W2050475053 cites W2059857557 @default.
- W2050475053 cites W2066232588 @default.
- W2050475053 cites W2078220022 @default.
- W2050475053 cites W2080168163 @default.
- W2050475053 cites W2103716690 @default.
- W2050475053 cites W2104874810 @default.
- W2050475053 cites W2106078386 @default.
- W2050475053 cites W2112598476 @default.
- W2050475053 cites W2114280060 @default.
- W2050475053 cites W2115479667 @default.
- W2050475053 cites W2119412739 @default.
- W2050475053 cites W2121832625 @default.
- W2050475053 cites W2124621808 @default.
- W2050475053 cites W2132902066 @default.
- W2050475053 cites W2140828933 @default.
- W2050475053 cites W2153075964 @default.
- W2050475053 cites W2160798555 @default.
- W2050475053 cites W2161881247 @default.
- W2050475053 doi "https://doi.org/10.1002/jcb.23232" @default.
- W2050475053 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21678479" @default.
- W2050475053 hasPublicationYear "2011" @default.
- W2050475053 type Work @default.
- W2050475053 sameAs 2050475053 @default.
- W2050475053 citedByCount "3" @default.
- W2050475053 countsByYear W20504750532022 @default.
- W2050475053 crossrefType "journal-article" @default.
- W2050475053 hasAuthorship W2050475053A5051405082 @default.
- W2050475053 hasAuthorship W2050475053A5063020503 @default.
- W2050475053 hasConcept C104317684 @default.
- W2050475053 hasConcept C142724271 @default.
- W2050475053 hasConcept C2776228421 @default.
- W2050475053 hasConcept C2777975735 @default.
- W2050475053 hasConcept C2781019175 @default.
- W2050475053 hasConcept C2781069245 @default.
- W2050475053 hasConcept C54355233 @default.
- W2050475053 hasConcept C70721500 @default.
- W2050475053 hasConcept C71924100 @default.
- W2050475053 hasConcept C86803240 @default.
- W2050475053 hasConceptScore W2050475053C104317684 @default.
- W2050475053 hasConceptScore W2050475053C142724271 @default.
- W2050475053 hasConceptScore W2050475053C2776228421 @default.
- W2050475053 hasConceptScore W2050475053C2777975735 @default.
- W2050475053 hasConceptScore W2050475053C2781019175 @default.
- W2050475053 hasConceptScore W2050475053C2781069245 @default.
- W2050475053 hasConceptScore W2050475053C54355233 @default.
- W2050475053 hasConceptScore W2050475053C70721500 @default.
- W2050475053 hasConceptScore W2050475053C71924100 @default.
- W2050475053 hasConceptScore W2050475053C86803240 @default.
- W2050475053 hasIssue "10" @default.
- W2050475053 hasLocation W20504750531 @default.
- W2050475053 hasLocation W20504750532 @default.
- W2050475053 hasOpenAccess W2050475053 @default.
- W2050475053 hasPrimaryLocation W20504750531 @default.
- W2050475053 hasRelatedWork W1985695373 @default.
- W2050475053 hasRelatedWork W2002128513 @default.
- W2050475053 hasRelatedWork W2065465688 @default.
- W2050475053 hasRelatedWork W2110949356 @default.
- W2050475053 hasRelatedWork W2128022675 @default.
- W2050475053 hasRelatedWork W2375721856 @default.
- W2050475053 hasRelatedWork W2972094210 @default.
- W2050475053 hasRelatedWork W2991839473 @default.
- W2050475053 hasRelatedWork W3029116816 @default.
- W2050475053 hasRelatedWork W3210687582 @default.
- W2050475053 hasVolume "112" @default.
- W2050475053 isParatext "false" @default.
- W2050475053 isRetracted "false" @default.
- W2050475053 magId "2050475053" @default.
- W2050475053 workType "article" @default.