FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050489308> ?p ?o ?g. }

• W2050489308 endingPage "360" @default.
• W2050489308 startingPage "354" @default.
• W2050489308 abstract "The late G1 surge of DNA polymerase-α activity and the initiation of DNA replication in the hepatocytes of partial hepatectomy-induced regenerating liver were severely reduced when the mitogenic partial hepatectomy was carried out in the hypocalcemic and 1,25(OH)2D3 (1α,25-dihydroxycholecalciferol)-deficient environment of parathyroidectomized (PTX) or thyroparathyroidectomized (TPTX) rats. These inhibitions were prevented in TPTX rats by a postpartial hepatectomy injection of 1,25(OH)2D3, which also restored blood calcium to normocalcemic levels. Inhibition of active DNA polymerase-α accumulation and initiation of DNA synthesis in TPTX rats were also completely prevented by prefeeding the rats a low phosphorus diet, which stopped the lowering of the blood levels of calcium and 1,25(OH)2D3 following parathyroid removal. These studies indicate that the rise of DNA polymerase-α activity and the initiation of DNA replication in regenerating liver are controlled by cellular processes that rely on normal blood levels of calcium and 1,25(OH)2D3. Because DNA polymerase-α is the third DNA replication enzyme (the others are ribonucleotide reductase and thymidylate synthase) that has been shown to depend on parathyroid hormone and/or the circulating levels of calcium and 1,25(OH)2D3 that it controls, the authors concluded that the processes dependent on calcium and 1,25(OH)2D3 are parts of a mechanism that coordinately activates the DNA-replicating enzymes. The possibility that cyclic adenosine monophosphate (cAMP)-dependent protein kinases are involved in this replication mechanism is considered." @default.
• W2050489308 created "2016-06-24" @default.
• W2050489308 creator A5005308464 @default.
• W2050489308 creator A5016390620 @default.
• W2050489308 creator A5056816179 @default.
• W2050489308 date "1989-05-01" @default.
• W2050489308 modified "2023-10-09" @default.
• W2050489308 title "Control of DNA polymerase-? activity in regenerating rat liver by calcium and 1?,25(OH)2D3" @default.
• W2050489308 cites W1505136621 @default.
• W2050489308 cites W1525488169 @default.
• W2050489308 cites W1592645517 @default.
• W2050489308 cites W1775749144 @default.
• W2050489308 cites W1965937833 @default.
• W2050489308 cites W1966652159 @default.
• W2050489308 cites W1983572538 @default.
• W2050489308 cites W1984394803 @default.
• W2050489308 cites W1986275053 @default.
• W2050489308 cites W1998218691 @default.
• W2050489308 cites W2009484872 @default.
• W2050489308 cites W2024551462 @default.
• W2050489308 cites W2027534900 @default.
• W2050489308 cites W2028759340 @default.
• W2050489308 cites W2029937953 @default.
• W2050489308 cites W2040640918 @default.
• W2050489308 cites W2045650911 @default.
• W2050489308 cites W2052405585 @default.
• W2050489308 cites W2063943977 @default.
• W2050489308 cites W2064595862 @default.
• W2050489308 cites W2092959403 @default.
• W2050489308 cites W2110223847 @default.
• W2050489308 cites W2160385278 @default.
• W2050489308 cites W2315479180 @default.
• W2050489308 cites W2327281300 @default.
• W2050489308 cites W2776359412 @default.
• W2050489308 cites W49560201 @default.
• W2050489308 cites W84102659 @default.
• W2050489308 cites W1995311643 @default.
• W2050489308 cites W2476329106 @default.
• W2050489308 doi "https://doi.org/10.1002/jcp.1041390218" @default.
• W2050489308 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2715191" @default.
• W2050489308 hasPublicationYear "1989" @default.
• W2050489308 type Work @default.
• W2050489308 sameAs 2050489308 @default.
• W2050489308 citedByCount "26" @default.
• W2050489308 countsByYear W20504893082013 @default.
• W2050489308 countsByYear W20504893082018 @default.
• W2050489308 countsByYear W20504893082020 @default.
• W2050489308 countsByYear W20504893082023 @default.
• W2050489308 crossrefType "journal-article" @default.
• W2050489308 hasAuthorship W2050489308A5005308464 @default.
• W2050489308 hasAuthorship W2050489308A5016390620 @default.
• W2050489308 hasAuthorship W2050489308A5056816179 @default.
• W2050489308 hasConcept C126322002 @default.
• W2050489308 hasConcept C134018914 @default.
• W2050489308 hasConcept C153911025 @default.
• W2050489308 hasConcept C181199279 @default.
• W2050489308 hasConcept C182420341 @default.
• W2050489308 hasConcept C185592680 @default.
• W2050489308 hasConcept C2756471 @default.
• W2050489308 hasConcept C2781208988 @default.
• W2050489308 hasConcept C519063684 @default.
• W2050489308 hasConcept C552990157 @default.
• W2050489308 hasConcept C55493867 @default.
• W2050489308 hasConcept C64241487 @default.
• W2050489308 hasConcept C71924100 @default.
• W2050489308 hasConcept C73573662 @default.
• W2050489308 hasConcept C82381507 @default.
• W2050489308 hasConcept C86803240 @default.
• W2050489308 hasConceptScore W2050489308C126322002 @default.
• W2050489308 hasConceptScore W2050489308C134018914 @default.
• W2050489308 hasConceptScore W2050489308C153911025 @default.
• W2050489308 hasConceptScore W2050489308C181199279 @default.
• W2050489308 hasConceptScore W2050489308C182420341 @default.
• W2050489308 hasConceptScore W2050489308C185592680 @default.
• W2050489308 hasConceptScore W2050489308C2756471 @default.
• W2050489308 hasConceptScore W2050489308C2781208988 @default.
• W2050489308 hasConceptScore W2050489308C519063684 @default.
• W2050489308 hasConceptScore W2050489308C552990157 @default.
• W2050489308 hasConceptScore W2050489308C55493867 @default.
• W2050489308 hasConceptScore W2050489308C64241487 @default.
• W2050489308 hasConceptScore W2050489308C71924100 @default.
• W2050489308 hasConceptScore W2050489308C73573662 @default.
• W2050489308 hasConceptScore W2050489308C82381507 @default.
• W2050489308 hasConceptScore W2050489308C86803240 @default.
• W2050489308 hasIssue "2" @default.
• W2050489308 hasLocation W20504893081 @default.
• W2050489308 hasLocation W20504893082 @default.
• W2050489308 hasOpenAccess W2050489308 @default.
• W2050489308 hasPrimaryLocation W20504893081 @default.
• W2050489308 hasRelatedWork W1486256981 @default.
• W2050489308 hasRelatedWork W1601249389 @default.
• W2050489308 hasRelatedWork W1644586516 @default.
• W2050489308 hasRelatedWork W1845090302 @default.
• W2050489308 hasRelatedWork W1968124126 @default.
• W2050489308 hasRelatedWork W2059024666 @default.
• W2050489308 hasRelatedWork W2062281408 @default.
• W2050489308 hasRelatedWork W2065071532 @default.
• W2050489308 hasRelatedWork W2084400210 @default.

• next