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- W2050497029 abstract "Pericytes are mural cells of the microcirculation that have been shown to play key roles in regulating microvascular morphogenesis and stability throughout each tissue bed and organ system assessed. Of note, recent work has revealed that pericytes share several characteristics with mesenchymal- and adipose-derived stem cells, suggesting there may be lineage-related connections among bona fide pericytes and these vascular progenitors, which can assume a perivascular position in association with endothelial cells. Hence, pericyte identity as a mediator of vascular remodeling may be confounded by its close relationships with its progenitors or pluripotent cell counterparts and yet demonstrates their potential utility as cell-based therapies for unmet clinical needs. Crucial to the development of such therapies is a comprehensive understanding of the origin and fate regulating these related cell types as well as the unveiling of the molecular mechanisms by which pericytes and endothelial cells communicate. Such mechanistic inputs, which disrupt normal cellular crosstalk during disease inception and progression, offer opportunities for intervention and are discussed in the context of the vasculopathies accompanying tumor growth, diabetes, and fibrosis." @default.
- W2050497029 created "2016-06-24" @default.
- W2050497029 creator A5013936846 @default.
- W2050497029 creator A5077822196 @default.
- W2050497029 date "2014-04-01" @default.
- W2050497029 modified "2023-10-06" @default.
- W2050497029 title "Pericyte-endothelial crosstalk: implications and opportunities for advanced cellular therapies" @default.
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- W2050497029 doi "https://doi.org/10.1016/j.trsl.2014.01.011" @default.
- W2050497029 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3976718" @default.
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- W2050497029 hasPublicationYear "2014" @default.
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