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• W2050515087 startingPage "354" @default.
• W2050515087 abstract "Many bacterial pathogens encode a multisubunit toxin, termed cytolethal distending toxin (CDT), that induces cell cycle arrest, cytoplasm distention, and, eventually, chromatin fragmentation and cell death. In one such pathogen, Campylobacter jejuni, one of the subunits of this toxin, CdtB, was shown to exhibit features of type I deoxyribonucleases. Transient expression of this subunit in cultured cells caused marked chromatin disruption. Microinjection of low amounts of CdtB induced cytoplasmic distention and cell cycle arrest. CdtB mutants with substitutions in residues equivalent to those required for catalysis or magnesium binding in type I deoxyribonucleases did not cause chromatin disruption. CDT holotoxin containing these mutant forms of CdtB did not induce morphological changes or cell cycle arrest." @default.
• W2050515087 created "2016-06-24" @default.
• W2050515087 creator A5016995233 @default.
• W2050515087 creator A5054420811 @default.
• W2050515087 date "2000-10-13" @default.
• W2050515087 modified "2023-10-18" @default.
• W2050515087 title "A Bacterial Toxin That Controls Cell Cycle Progression as a Deoxyribonuclease I-Like Protein" @default.
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• W2050515087 doi "https://doi.org/10.1126/science.290.5490.354" @default.
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