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- W2050517615 abstract "Genetic factors are known to contribute to seizure susceptibility, although the long-term effects of these predisposing factors on neuronal viability remain unclear. To examine the consequences of genetic factors conferring increased seizure susceptibility, we surveyed a class of Drosophila mutants that exhibit seizures and paralysis following mechanical stimulation. These bang-sensitive seizure mutants exhibit shortened life spans and age-dependent neurodegeneration. Because the increased seizure susceptibility in these mutants likely results from altered metabolism and since the Na(+)/K(+) ATPase consumes the majority of ATP in neurons, we examined the effect of ATPalpha mutations in combination with bang-sensitive mutations. We found that double mutants exhibit strikingly reduced life spans and age-dependent uncoordination and inactivity. These results emphasize the importance of proper cellular metabolism in maintaining both the activity and viability of neurons." @default.
- W2050517615 created "2016-06-24" @default.
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- W2050517615 date "2008-02-01" @default.
- W2050517615 modified "2023-10-16" @default.
- W2050517615 title "Neuropathology in Drosophila Mutants With Increased Seizure Susceptibility" @default.
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- W2050517615 doi "https://doi.org/10.1534/genetics.107.082115" @default.
- W2050517615 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2248337" @default.
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