Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050522119> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2050522119 endingPage "6" @default.
- W2050522119 startingPage "283" @default.
- W2050522119 abstract "In view of the data indicating that insulin can modify penetration of some drugs across cell membranes and tissue barriers, particularly the blood-brain barrier, the aim of the present study was to evaluate the effect of insulin on both the anticonvulsant activity and the brain concentration of carbamazepine in mice suffering from seizures induced by maximal electroshock. The antiepileptic drug was administered per os in single doses either alone or in combination with insulin given as single intraperitoneal injections. To assess the anticonvulsant activity of carbamazepine the ED50 values were calculated. The results indicate that insulin given in doses up to 2 units/kg did not affect the convulsive threshold, whereas insulin applied at 2 units/kg led to a significant reduction in the anticonvulsant activity of carbamazepine, as judged by an increase in the ED50 value from 16.2 to 41.3 mg/kg. This effect was accompanied by the marked reduction in both the brain and blood concentrations of the drug. It is likely, therefore, that the inhibitory activity of insulin on the anticonvulsive function of carbamazepine is related not only to the effect of the former on the blood-brain transport of the latter, but also to insulin-induced modulation of the serum concentration of the drug." @default.
- W2050522119 created "2016-06-24" @default.
- W2050522119 creator A5008024647 @default.
- W2050522119 creator A5028431751 @default.
- W2050522119 creator A5030214844 @default.
- W2050522119 creator A5085080006 @default.
- W2050522119 date "1998-01-01" @default.
- W2050522119 modified "2023-09-24" @default.
- W2050522119 title "Insulin impairs the anticonvulsive activity of carbamazepine against maximal electroshock-induced seizures in mice." @default.
- W2050522119 cites W2013566224 @default.
- W2050522119 cites W2033336706 @default.
- W2050522119 cites W2036143663 @default.
- W2050522119 cites W2056371171 @default.
- W2050522119 cites W2081820987 @default.
- W2050522119 cites W2259516905 @default.
- W2050522119 cites W2410215456 @default.
- W2050522119 cites W2411260557 @default.
- W2050522119 cites W2430891649 @default.
- W2050522119 cites W2885109878 @default.
- W2050522119 cites W59993581 @default.
- W2050522119 cites W613616224 @default.
- W2050522119 cites W2003254129 @default.
- W2050522119 cites W2154277990 @default.
- W2050522119 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9949555" @default.
- W2050522119 hasPublicationYear "1998" @default.
- W2050522119 type Work @default.
- W2050522119 sameAs 2050522119 @default.
- W2050522119 citedByCount "0" @default.
- W2050522119 crossrefType "journal-article" @default.
- W2050522119 hasAuthorship W2050522119A5008024647 @default.
- W2050522119 hasAuthorship W2050522119A5028431751 @default.
- W2050522119 hasAuthorship W2050522119A5030214844 @default.
- W2050522119 hasAuthorship W2050522119A5085080006 @default.
- W2050522119 hasConcept C118552586 @default.
- W2050522119 hasConcept C126322002 @default.
- W2050522119 hasConcept C134018914 @default.
- W2050522119 hasConcept C170493617 @default.
- W2050522119 hasConcept C185592680 @default.
- W2050522119 hasConcept C2775858608 @default.
- W2050522119 hasConcept C2778186239 @default.
- W2050522119 hasConcept C2779253243 @default.
- W2050522119 hasConcept C2779306644 @default.
- W2050522119 hasConcept C2780035454 @default.
- W2050522119 hasConcept C42533223 @default.
- W2050522119 hasConcept C71924100 @default.
- W2050522119 hasConcept C97320921 @default.
- W2050522119 hasConcept C98274493 @default.
- W2050522119 hasConceptScore W2050522119C118552586 @default.
- W2050522119 hasConceptScore W2050522119C126322002 @default.
- W2050522119 hasConceptScore W2050522119C134018914 @default.
- W2050522119 hasConceptScore W2050522119C170493617 @default.
- W2050522119 hasConceptScore W2050522119C185592680 @default.
- W2050522119 hasConceptScore W2050522119C2775858608 @default.
- W2050522119 hasConceptScore W2050522119C2778186239 @default.
- W2050522119 hasConceptScore W2050522119C2779253243 @default.
- W2050522119 hasConceptScore W2050522119C2779306644 @default.
- W2050522119 hasConceptScore W2050522119C2780035454 @default.
- W2050522119 hasConceptScore W2050522119C42533223 @default.
- W2050522119 hasConceptScore W2050522119C71924100 @default.
- W2050522119 hasConceptScore W2050522119C97320921 @default.
- W2050522119 hasConceptScore W2050522119C98274493 @default.
- W2050522119 hasIssue "4" @default.
- W2050522119 hasLocation W20505221191 @default.
- W2050522119 hasOpenAccess W2050522119 @default.
- W2050522119 hasPrimaryLocation W20505221191 @default.
- W2050522119 hasRelatedWork W1974793030 @default.
- W2050522119 hasRelatedWork W2005179275 @default.
- W2050522119 hasRelatedWork W2037205718 @default.
- W2050522119 hasRelatedWork W2037680891 @default.
- W2050522119 hasRelatedWork W2050522119 @default.
- W2050522119 hasRelatedWork W2071192356 @default.
- W2050522119 hasRelatedWork W2074579699 @default.
- W2050522119 hasRelatedWork W2243166944 @default.
- W2050522119 hasRelatedWork W2321017412 @default.
- W2050522119 hasRelatedWork W2463051206 @default.
- W2050522119 hasVolume "58" @default.
- W2050522119 isParatext "false" @default.
- W2050522119 isRetracted "false" @default.
- W2050522119 magId "2050522119" @default.
- W2050522119 workType "article" @default.