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- W2050524321 abstract "We survey computational approaches that tackle membrane protein structure and function prediction. While describing the main ideas that have led to the development of the most relevant and novel methods, we also discuss pitfalls, provide practical hints and highlight the challenges that remain. The methods covered include: sequence alignment, motif search, functional residue identification, transmembrane segment and protein topology predictions, homology and ab initio modeling. In general, predictions of functional and structural features of membrane proteins are improving, although progress is hampered by the limited amount of high-resolution experimental information available. While predictions of transmembrane segments and protein topology rank among the most accurate methods in computational biology, more attention and effort will be required in the future to ameliorate database search, homology and ab initio modeling." @default.
- W2050524321 created "2016-06-24" @default.
- W2050524321 creator A5010395023 @default.
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- W2050524321 creator A5064905883 @default.
- W2050524321 creator A5068406248 @default.
- W2050524321 creator A5077523403 @default.
- W2050524321 date "2007-04-01" @default.
- W2050524321 modified "2023-10-10" @default.
- W2050524321 title "Membrane protein prediction methods" @default.
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