Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050533211> ?p ?o ?g. }
- W2050533211 endingPage "675" @default.
- W2050533211 startingPage "667" @default.
- W2050533211 abstract "Over the past 100 years, animal infectious disease research has played a crucial role in the development of human vaccines. In fact, many of today's vaccines are based on utilizing animal pathogens, either in the form of an attenuated vaccine or as a vaccine vector. Vaccine development has become increasingly complex with chronic and newly emerging diseases, a demand for therapeutic vaccines for noninfectious diseases, extended vaccine in the neonate and the elderly, and increasing concerns regarding vaccine safety. Furthermore, the evaluation of quantity and quality of immune responses and the ability to efficiently translate the results of basic research into the clinic are critical to ensure that vaccines meet their therapeutic potential. Here, we review the importance of animal models for developing and testing novel human vaccines, discuss the limitations of existing animal models in knowledge translation, and summarize the needs and criteria for future animal models. We argue that efficient translation of basic vaccine research to clinical therapies will depend upon the availability of appropriate animal models to address each of the questions which arise during vaccine development." @default.
- W2050533211 created "2016-06-24" @default.
- W2050533211 creator A5047258184 @default.
- W2050533211 creator A5054537882 @default.
- W2050533211 creator A5079330921 @default.
- W2050533211 creator A5084967847 @default.
- W2050533211 date "2007-12-01" @default.
- W2050533211 modified "2023-10-01" @default.
- W2050533211 title "Use of animal models in the development of human vaccines" @default.
- W2050533211 cites W142042550 @default.
- W2050533211 cites W1541863011 @default.
- W2050533211 cites W1591865329 @default.
- W2050533211 cites W1593595005 @default.
- W2050533211 cites W1604178450 @default.
- W2050533211 cites W1872132413 @default.
- W2050533211 cites W1964955447 @default.
- W2050533211 cites W1968495801 @default.
- W2050533211 cites W1973493403 @default.
- W2050533211 cites W1977141229 @default.
- W2050533211 cites W1980175064 @default.
- W2050533211 cites W1983458029 @default.
- W2050533211 cites W1984591972 @default.
- W2050533211 cites W1986093685 @default.
- W2050533211 cites W2007632362 @default.
- W2050533211 cites W2015833555 @default.
- W2050533211 cites W2022690205 @default.
- W2050533211 cites W2023179470 @default.
- W2050533211 cites W2023982543 @default.
- W2050533211 cites W2029404175 @default.
- W2050533211 cites W2035400019 @default.
- W2050533211 cites W2040680109 @default.
- W2050533211 cites W2048119481 @default.
- W2050533211 cites W2048172239 @default.
- W2050533211 cites W2049095033 @default.
- W2050533211 cites W2049910116 @default.
- W2050533211 cites W2050849651 @default.
- W2050533211 cites W2052971734 @default.
- W2050533211 cites W2053397231 @default.
- W2050533211 cites W2053455224 @default.
- W2050533211 cites W206209223 @default.
- W2050533211 cites W2065231269 @default.
- W2050533211 cites W2068555098 @default.
- W2050533211 cites W2071082533 @default.
- W2050533211 cites W2072245133 @default.
- W2050533211 cites W2076176349 @default.
- W2050533211 cites W2082685683 @default.
- W2050533211 cites W2085936848 @default.
- W2050533211 cites W2086937330 @default.
- W2050533211 cites W2089505575 @default.
- W2050533211 cites W2093437681 @default.
- W2050533211 cites W2107281588 @default.
- W2050533211 cites W2126043466 @default.
- W2050533211 cites W2140917849 @default.
- W2050533211 cites W2144201356 @default.
- W2050533211 cites W2160049798 @default.
- W2050533211 cites W2161291046 @default.
- W2050533211 cites W2162543584 @default.
- W2050533211 cites W2169784600 @default.
- W2050533211 cites W2209144327 @default.
- W2050533211 cites W3043125680 @default.
- W2050533211 cites W4238439257 @default.
- W2050533211 doi "https://doi.org/10.2217/17460913.2.6.667" @default.
- W2050533211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18041907" @default.
- W2050533211 hasPublicationYear "2007" @default.
- W2050533211 type Work @default.
- W2050533211 sameAs 2050533211 @default.
- W2050533211 citedByCount "43" @default.
- W2050533211 countsByYear W20505332112012 @default.
- W2050533211 countsByYear W20505332112013 @default.
- W2050533211 countsByYear W20505332112014 @default.
- W2050533211 countsByYear W20505332112015 @default.
- W2050533211 countsByYear W20505332112016 @default.
- W2050533211 countsByYear W20505332112017 @default.
- W2050533211 countsByYear W20505332112018 @default.
- W2050533211 countsByYear W20505332112019 @default.
- W2050533211 countsByYear W20505332112020 @default.
- W2050533211 countsByYear W20505332112021 @default.
- W2050533211 countsByYear W20505332112022 @default.
- W2050533211 crossrefType "journal-article" @default.
- W2050533211 hasAuthorship W2050533211A5047258184 @default.
- W2050533211 hasAuthorship W2050533211A5054537882 @default.
- W2050533211 hasAuthorship W2050533211A5079330921 @default.
- W2050533211 hasAuthorship W2050533211A5084967847 @default.
- W2050533211 hasConcept C112930515 @default.
- W2050533211 hasConcept C134018914 @default.
- W2050533211 hasConcept C142724271 @default.
- W2050533211 hasConcept C150903083 @default.
- W2050533211 hasConcept C177713679 @default.
- W2050533211 hasConcept C19527891 @default.
- W2050533211 hasConcept C203014093 @default.
- W2050533211 hasConcept C2778117688 @default.
- W2050533211 hasConcept C2779134260 @default.
- W2050533211 hasConcept C2988867146 @default.
- W2050533211 hasConcept C2993043200 @default.
- W2050533211 hasConcept C3020792226 @default.
- W2050533211 hasConcept C524204448 @default.
- W2050533211 hasConcept C71924100 @default.
- W2050533211 hasConcept C86803240 @default.