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- W2050543389 abstract "Alzheimer's disease (AD) is an age-related neurological disorder characterized by synaptic loss and dementia. The low-density lipoprotein receptor-related protein 6 (LRP6) is an essential coreceptor for Wnt signaling, and its genetic variants have been linked to AD risk. Here we report that neuronal LRP6-mediated Wnt signaling is critical for synaptic function and cognition. Conditional deletion of Lrp6 gene in mouse forebrain neurons leads to age-dependent deficits in synaptic integrity and memory. Neuronal LRP6 deficiency in an amyloid mouse model also leads to exacerbated amyloid pathology due to increased APP processing to amyloid-β. In humans, LRP6 and Wnt signaling are significantly downregulated in AD brains, likely by a mechanism that depends on amyloid-β. Our results define a critical pathway in which decreased LRP6-mediated Wnt signaling, synaptic dysfunction, and elevated Aβ synergistically accelerate AD progression and suggest that restoring LRP6-mediated Wnt signaling can be explored as a viable strategy for AD therapy." @default.
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- W2050543389 date "2014-10-01" @default.
- W2050543389 modified "2023-10-17" @default.
- W2050543389 title "Deficiency in LRP6-Mediated Wnt Signaling Contributes to Synaptic Abnormalities and Amyloid Pathology in Alzheimer’s Disease" @default.
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- W2050543389 cites W1957957030 @default.
- W2050543389 cites W1963836337 @default.
- W2050543389 cites W1964927015 @default.
- W2050543389 cites W1970211293 @default.
- W2050543389 cites W1973526162 @default.
- W2050543389 cites W1984001932 @default.
- W2050543389 cites W1987914057 @default.
- W2050543389 cites W1989771766 @default.
- W2050543389 cites W1996499871 @default.
- W2050543389 cites W1998306901 @default.
- W2050543389 cites W2002181764 @default.
- W2050543389 cites W2002937059 @default.
- W2050543389 cites W2005483591 @default.
- W2050543389 cites W2013891209 @default.
- W2050543389 cites W2016020712 @default.
- W2050543389 cites W2024370562 @default.
- W2050543389 cites W2027317254 @default.
- W2050543389 cites W2030223062 @default.
- W2050543389 cites W2032465593 @default.
- W2050543389 cites W2032607393 @default.
- W2050543389 cites W2038733641 @default.
- W2050543389 cites W2044836636 @default.
- W2050543389 cites W2045141662 @default.
- W2050543389 cites W2050222746 @default.
- W2050543389 cites W2051907575 @default.
- W2050543389 cites W2056313099 @default.
- W2050543389 cites W2066305765 @default.
- W2050543389 cites W2066464418 @default.
- W2050543389 cites W2068107037 @default.
- W2050543389 cites W2070567106 @default.
- W2050543389 cites W2072737785 @default.
- W2050543389 cites W2073790220 @default.
- W2050543389 cites W2074839194 @default.
- W2050543389 cites W2076155053 @default.
- W2050543389 cites W2079938040 @default.
- W2050543389 cites W2087745495 @default.
- W2050543389 cites W2089071918 @default.
- W2050543389 cites W2092517981 @default.
- W2050543389 cites W2096610613 @default.
- W2050543389 cites W2109281837 @default.
- W2050543389 cites W2109727228 @default.
- W2050543389 cites W2111994753 @default.
- W2050543389 cites W2115932454 @default.
- W2050543389 cites W2116342814 @default.
- W2050543389 cites W2116910809 @default.
- W2050543389 cites W2118129085 @default.
- W2050543389 cites W2119413986 @default.
- W2050543389 cites W2127700980 @default.
- W2050543389 cites W2129495914 @default.
- W2050543389 cites W2129720310 @default.
- W2050543389 cites W2130087890 @default.
- W2050543389 cites W2133659563 @default.
- W2050543389 cites W2136827845 @default.
- W2050543389 cites W2142943752 @default.
- W2050543389 cites W2143016634 @default.
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- W2050543389 cites W2147636813 @default.
- W2050543389 cites W2148294117 @default.
- W2050543389 cites W2148714108 @default.
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- W2050543389 cites W2168887286 @default.
- W2050543389 cites W2170194816 @default.
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- W2050543389 doi "https://doi.org/10.1016/j.neuron.2014.08.048" @default.
- W2050543389 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4199382" @default.
- W2050543389 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25242217" @default.
- W2050543389 hasPublicationYear "2014" @default.
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