FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050553698> ?p ?o ?g. }

• W2050553698 endingPage "9899" @default.
• W2050553698 startingPage "9887" @default.
• W2050553698 abstract "The widespread use of silver nanoparticles (Ag-NPs) in consumer and medical products provides strong motivation for a careful assessment of their environmental and human health risks. Recent studies have shown that Ag-NPs released to the natural environment undergo profound chemical transformations that can affect silver bioavailability, toxicity, and risk. Less is known about Ag-NP chemical transformations in biological systems, though the medical literature clearly reports that chronic silver ingestion produces argyrial deposits consisting of silver-, sulfur-, and selenium-containing particulate phases. Here we show that Ag-NPs undergo a rich set of biochemical transformations, including accelerated oxidative dissolution in gastric acid, thiol binding and exchange, photoreduction of thiol- or protein-bound silver to secondary zerovalent Ag-NPs, and rapid reactions between silver surfaces and reduced selenium species. Selenide is also observed to rapidly exchange with sulfide in preformed Ag(2)S solid phases. The combined results allow us to propose a conceptual model for Ag-NP transformation pathways in the human body. In this model, argyrial silver deposits are not translocated engineered Ag-NPs, but rather secondary particles formed by partial dissolution in the GI tract followed by ion uptake, systemic circulation as organo-Ag complexes, and immobilization as zerovalent Ag-NPs by photoreduction in light-affected skin regions. The secondary Ag-NPs then undergo detoxifying transformations into sulfides and further into selenides or Se/S mixed phases through exchange reactions. The formation of secondary particles in biological environments implies that Ag-NPs are not only a product of industrial nanotechnology but also have long been present in the human body following exposure to more traditional chemical forms of silver." @default.
• W2050553698 created "2016-06-24" @default.
• W2050553698 creator A5012413299 @default.
• W2050553698 creator A5066292657 @default.
• W2050553698 creator A5077124777 @default.
• W2050553698 creator A5082239675 @default.
• W2050553698 creator A5084812584 @default.
• W2050553698 date "2012-10-17" @default.
• W2050553698 modified "2023-09-30" @default.
• W2050553698 title "Chemical Transformations of Nanosilver in Biological Environments" @default.
• W2050553698 cites W144413805 @default.
• W2050553698 cites W1487072223 @default.
• W2050553698 cites W1539914843 @default.
• W2050553698 cites W1906797857 @default.
• W2050553698 cites W1963700481 @default.
• W2050553698 cites W1967110053 @default.
• W2050553698 cites W1970411171 @default.
• W2050553698 cites W1971291382 @default.
• W2050553698 cites W1972870712 @default.
• W2050553698 cites W1972934255 @default.
• W2050553698 cites W1978704826 @default.
• W2050553698 cites W1978883528 @default.
• W2050553698 cites W1981224435 @default.
• W2050553698 cites W1987270707 @default.
• W2050553698 cites W1987518520 @default.
• W2050553698 cites W1988538474 @default.
• W2050553698 cites W1990663869 @default.
• W2050553698 cites W1992725478 @default.
• W2050553698 cites W1996425316 @default.
• W2050553698 cites W1996896511 @default.
• W2050553698 cites W1997000819 @default.
• W2050553698 cites W1997336909 @default.
• W2050553698 cites W1998093075 @default.
• W2050553698 cites W1999978156 @default.
• W2050553698 cites W2000405970 @default.
• W2050553698 cites W2005815430 @default.
• W2050553698 cites W2006033584 @default.
• W2050553698 cites W2009124132 @default.
• W2050553698 cites W2009792330 @default.
• W2050553698 cites W2012481624 @default.
• W2050553698 cites W2014690173 @default.
• W2050553698 cites W2016972840 @default.
• W2050553698 cites W2017335462 @default.
• W2050553698 cites W2020446606 @default.
• W2050553698 cites W2021009186 @default.
• W2050553698 cites W2027392699 @default.
• W2050553698 cites W2032194545 @default.
• W2050553698 cites W2033057329 @default.
• W2050553698 cites W2036469767 @default.
• W2050553698 cites W2040107579 @default.
• W2050553698 cites W2040231410 @default.
• W2050553698 cites W2043495094 @default.
• W2050553698 cites W2044299763 @default.
• W2050553698 cites W2051690490 @default.
• W2050553698 cites W2054047714 @default.
• W2050553698 cites W2057036895 @default.
• W2050553698 cites W2057268637 @default.
• W2050553698 cites W2058457363 @default.
• W2050553698 cites W2059581884 @default.
• W2050553698 cites W2061528988 @default.
• W2050553698 cites W2062144566 @default.
• W2050553698 cites W2067430692 @default.
• W2050553698 cites W2067944056 @default.
• W2050553698 cites W2073298694 @default.
• W2050553698 cites W2077950519 @default.
• W2050553698 cites W2078287490 @default.
• W2050553698 cites W2079402489 @default.
• W2050553698 cites W2085850332 @default.
• W2050553698 cites W2087508899 @default.
• W2050553698 cites W2089830385 @default.
• W2050553698 cites W2091705326 @default.
• W2050553698 cites W2093428111 @default.
• W2050553698 cites W2094262202 @default.
• W2050553698 cites W2094428846 @default.
• W2050553698 cites W2095236112 @default.
• W2050553698 cites W2098770714 @default.
• W2050553698 cites W2103492103 @default.
• W2050553698 cites W2104626279 @default.
• W2050553698 cites W2105260571 @default.
• W2050553698 cites W2105398112 @default.
• W2050553698 cites W2121990753 @default.
• W2050553698 cites W2126083122 @default.
• W2050553698 cites W2128708209 @default.
• W2050553698 cites W2132360453 @default.
• W2050553698 cites W2136390164 @default.
• W2050553698 cites W2137079739 @default.
• W2050553698 cites W2143126720 @default.
• W2050553698 cites W2144874527 @default.
• W2050553698 cites W2145167640 @default.
• W2050553698 cites W2146385374 @default.
• W2050553698 cites W2147385559 @default.
• W2050553698 cites W2152604288 @default.
• W2050553698 cites W2161325709 @default.
• W2050553698 cites W2164760296 @default.
• W2050553698 cites W2314438163 @default.
• W2050553698 cites W2328984514 @default.
• W2050553698 cites W2330135458 @default.
• W2050553698 cites W23305180 @default.

• next