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• W2050554410 abstract "Dietary supplementation with fish oil has previously been shown to enhance in vivo and in vitro (macrophage) synthesis of tumor necrosis factor-alpha (TNF-α) in response to bacterial lipopolysaccharide (LPS) stimulation. The studies reported here were conducted to gain insight into the molecular mechanisms of this nutrient-immune interaction by comparing the concentration, rate of synthesis, and rate of decay of TNF-α mRNA upon LPS stimulation of macrophages obtained from mice fed high-fat diets, rich in either fish oil, corn oil, or coconut oil, or a low-fat diet for a period of 4 weeks. The results indicate that compared with the other diet groups, LPS stimulation of macrophages from mice fed fish oil resulted in (1) enhanced levels of mRNA and protein for TNF-α, and (2) increased transcription of TNF-α mRNA as assessed by nuclear run-on assays. Posttranscriptional studies showed that the rate of decay of TNF-α mRNA did not vary significantly for macrophages from mice fed with fish oil as compared with corn oil. Further studies using actinomycin D and cycloheximide suggested that RNA synthesis, but not protein synthesis, was necessary for TNF-α mRNA accumulation. Taken together, the present studies suggest that fish oil enhances macrophage TNF-α mRNA expression at the transcriptional level. Although such TNF-α upregulation may provide a mechanism for the beneficial effects of fish oil in certain inflammatory and immune disorders, it can also underlie its potential deleterious effects if the degree of upregulation leads to exaggerated TNF-α production that exceeds the limits of benefit to reach toxic levels." @default.
• W2050554410 created "2016-06-24" @default.
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• W2050554410 date "1995-06-01" @default.
• W2050554410 modified "2023-10-18" @default.
• W2050554410 title "Fish oil enhances macrophage tumor necrosis factor-alpha mRNA expression at the transcriptional level" @default.
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• W2050554410 doi "https://doi.org/10.1016/0026-0495(95)90196-5" @default.
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