FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050573030> ?p ?o ?g. }

• W2050573030 endingPage "491" @default.
• W2050573030 startingPage "482" @default.
• W2050573030 abstract "Immobility in the tail suspension test (TST) is considered a model of despair in a stressful situation, and acute treatment with antidepressants reduces immobility. Inbred strains of mouse exhibit widely differing baseline levels of immobility in the TST and several quantitative trait loci (QTLs) have been nominated. The labor of manual scoring and various scoring criteria make obtaining robust data and comparisons across different laboratories problematic. Several studies have validated strain gauge and video analysis methods by comparison with manual scoring. We set out to find objective criteria for automated scoring parameters that maximize the biological information obtained, using a video tracking system on tapes of tail suspension tests of 24 lines of the BXD recombinant inbred panel and the progenitor strains C57BL/6J and DBA/2J. The maximum genetic effect size is captured using the highest time resolution and a low mobility threshold. Dissecting the trait further by comparing genetic association of multiple measures reveals good evidence for loci involved in immobility on chromosomes 4 and 15. These are best seen when using a high threshold for immobility, despite the overall better heritability at the lower threshold. A second trial of the test has greater duration of immobility and a completely different genetic profile. Frequency of mobility is also an independent phenotype, with a distal chromosome 1 locus." @default.
• W2050573030 created "2016-06-24" @default.
• W2050573030 creator A5023917031 @default.
• W2050573030 creator A5031853157 @default.
• W2050573030 creator A5056263103 @default.
• W2050573030 creator A5057837314 @default.
• W2050573030 creator A5063887873 @default.
• W2050573030 date "2007-07-01" @default.
• W2050573030 modified "2023-10-02" @default.
• W2050573030 title "Quantitative traits for the tail suspension test: automation, optimization, and BXD RI mapping" @default.
• W2050573030 cites W1561090959 @default.
• W2050573030 cites W1598387617 @default.
• W2050573030 cites W1612613395 @default.
• W2050573030 cites W1900227502 @default.
• W2050573030 cites W1914747759 @default.
• W2050573030 cites W1978310063 @default.
• W2050573030 cites W1984365975 @default.
• W2050573030 cites W1992545934 @default.
• W2050573030 cites W1992656698 @default.
• W2050573030 cites W1995507012 @default.
• W2050573030 cites W2005594217 @default.
• W2050573030 cites W2009249193 @default.
• W2050573030 cites W2016095427 @default.
• W2050573030 cites W2027448883 @default.
• W2050573030 cites W2037111632 @default.
• W2050573030 cites W2048117080 @default.
• W2050573030 cites W2065062587 @default.
• W2050573030 cites W2073455107 @default.
• W2050573030 cites W2074724278 @default.
• W2050573030 cites W2075609074 @default.
• W2050573030 cites W2075654334 @default.
• W2050573030 cites W2078056744 @default.
• W2050573030 cites W2084889414 @default.
• W2050573030 cites W2086554774 @default.
• W2050573030 cites W2086985992 @default.
• W2050573030 cites W2088620464 @default.
• W2050573030 cites W2092575483 @default.
• W2050573030 cites W2097241494 @default.
• W2050573030 cites W2102756115 @default.
• W2050573030 cites W2108334325 @default.
• W2050573030 cites W2116053845 @default.
• W2050573030 cites W2118727272 @default.
• W2050573030 cites W2150002111 @default.
• W2050573030 cites W2171070506 @default.
• W2050573030 cites W2496781379 @default.
• W2050573030 doi "https://doi.org/10.1007/s00335-007-9029-1" @default.
• W2050573030 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1998875" @default.
• W2050573030 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17619104" @default.
• W2050573030 hasPublicationYear "2007" @default.
• W2050573030 type Work @default.
• W2050573030 sameAs 2050573030 @default.
• W2050573030 citedByCount "27" @default.
• W2050573030 countsByYear W20505730302012 @default.
• W2050573030 countsByYear W20505730302013 @default.
• W2050573030 countsByYear W20505730302015 @default.
• W2050573030 countsByYear W20505730302016 @default.
• W2050573030 countsByYear W20505730302018 @default.
• W2050573030 countsByYear W20505730302019 @default.
• W2050573030 countsByYear W20505730302021 @default.
• W2050573030 countsByYear W20505730302022 @default.
• W2050573030 countsByYear W20505730302023 @default.
• W2050573030 crossrefType "journal-article" @default.
• W2050573030 hasAuthorship W2050573030A5023917031 @default.
• W2050573030 hasAuthorship W2050573030A5031853157 @default.
• W2050573030 hasAuthorship W2050573030A5056263103 @default.
• W2050573030 hasAuthorship W2050573030A5057837314 @default.
• W2050573030 hasAuthorship W2050573030A5063887873 @default.
• W2050573030 hasBestOaLocation W20505730301 @default.
• W2050573030 hasConcept C104317684 @default.
• W2050573030 hasConcept C161890455 @default.
• W2050573030 hasConcept C54355233 @default.
• W2050573030 hasConcept C76725341 @default.
• W2050573030 hasConcept C81941488 @default.
• W2050573030 hasConcept C84597430 @default.
• W2050573030 hasConcept C86803240 @default.
• W2050573030 hasConceptScore W2050573030C104317684 @default.
• W2050573030 hasConceptScore W2050573030C161890455 @default.
• W2050573030 hasConceptScore W2050573030C54355233 @default.
• W2050573030 hasConceptScore W2050573030C76725341 @default.
• W2050573030 hasConceptScore W2050573030C81941488 @default.
• W2050573030 hasConceptScore W2050573030C84597430 @default.
• W2050573030 hasConceptScore W2050573030C86803240 @default.
• W2050573030 hasIssue "6-7" @default.
• W2050573030 hasLocation W20505730301 @default.
• W2050573030 hasLocation W20505730302 @default.
• W2050573030 hasLocation W20505730303 @default.
• W2050573030 hasLocation W20505730304 @default.
• W2050573030 hasLocation W20505730305 @default.
• W2050573030 hasLocation W20505730306 @default.
• W2050573030 hasOpenAccess W2050573030 @default.
• W2050573030 hasPrimaryLocation W20505730301 @default.
• W2050573030 hasRelatedWork W1685382538 @default.
• W2050573030 hasRelatedWork W1828691184 @default.
• W2050573030 hasRelatedWork W1905165811 @default.
• W2050573030 hasRelatedWork W1996810298 @default.
• W2050573030 hasRelatedWork W2018900847 @default.
• W2050573030 hasRelatedWork W2052322658 @default.
• W2050573030 hasRelatedWork W2057739827 @default.

• next