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• W2050576556 abstract "In previous studies the rate of left ventricular (LV) volume change during the first third of systole was shown to be a more sensitive index of cardiac performance than ejection fraction (EF) in coronary disease. To test the hypothesis that a noninvasive index of the ejection rate in early systole can also identify subtle abnormalities of LV performance in aortic regurgitation (AR), the rate of change of LV counts during the first third of systole was measured by first-pass radionuclide angiography (RNV) in 34 AR patients and in 10 normal controls. By least squares analysis a straight line was fit to the LV counts obtained at 0.025 second intervals during the first third of systole; the slope was divided by the average counts in the first third to give a rate constant (RC) proportional to LV volume change during early systole. The AR patients were divided into two groups based upon the response of EF to exercise (ΔEF). A normal response was defined as a rise equal to or greater than 5%. Group 1 comprised 19 AR patients with a normal EF response to exercise (from 60 ± 9% to 70 ± 9%), and group 2 comprised 15 AR patients with an abnormal EF response to exercise (from 58 ± 9% to 52 ± 10%). The RC obtained at rest was 9.4 ± 2.8 for group 2, significantly lower than for group 1 (15.6 ± 3.9) or controls (14.9 ± 2.6) (p 12.0. When RC was plotted vs EF for all 44 individuals, there was a significant direct relationship, r = 0.74 (p < 0.01), but with wide confidence limits. These data indicate that a noninvasive index of the rate of LV volume change during the first third of systole can identify abnormal LV reserve in AR patients with normal EF at rest." @default.
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• W2050576556 date "1982-07-01" @default.
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• W2050576556 title "Radionuclide angiographic evaluation of left ventricular function by resting ejection rate during the first third of systole in patients with chronic aortic regurgitation" @default.
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• W2050576556 doi "https://doi.org/10.1016/0002-8703(82)90646-9" @default.
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