FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050582064> ?p ?o ?g. }

• W2050582064 endingPage "392" @default.
• W2050582064 startingPage "377" @default.
• W2050582064 abstract "Many unexpected biological functions as bioreactants of the intracellular proteases and their endogenous inhibitors have been found recently. Chymase and tryptase in histamine granules of mast cells and basophile cells play an important role in the process of IgE-mediated degranulation and in the formation of an allergic inflammation profile. Furthermore, the relationship between membrane proteases and their endogenous inhibitor has been taken up as a key and key-hole relation which plays an important role for special recognition apparatus of biological information like the relation of peptide hormones (growth factors) and their specific receptors. Amino acid sequences of the active site of trypstatin are homologous with the neutralizing epitope β of gp120 of AIDS virus (HIV-1). The trypstatin and anti-tryptase M antibody inhibited syncytium formation in HIV infected Molt 4, clone 8 cells. Therefore, the relationship between tryptase M with trypstatin and the recognition site of epitope β of HIV-1 with the receptor of helper T-cells are the common keys. The precursor of Alzheimer's deposition protein contains a Kunitz-type trypsin inhibitor domain. The A4-precursor proteins are located in axons of pyramidal neurons in brain and secretory granules of chromaffin cells in adrenal medulla. Those may be secreted into the extracellular milieu. We propose that the A4 inhibitor inhibits a special type of tryptase in the brain and disturbs the complete degradation of secreted A4-precursor protein causing amyloid deposition in alzheimer disease by abnormal proteolysis. Human c-Ha-ras p21 shows 58% homology with cystatin β, an endogenous inhibitor of cathepsin. Actually, p21 inhibits cathepsin L specifically, but not cathepsin H, papain and cathepsin B. However, the metabolic significance of this inhibitory activity is still unknown." @default.
• W2050582064 created "2016-06-24" @default.
• W2050582064 creator A5026359029 @default.
• W2050582064 date "1990-01-01" @default.
• W2050582064 modified "2023-10-16" @default.
• W2050582064 title "New biological functions of intracellular proteases and their endogenous inhibitors as bioreactants" @default.
• W2050582064 cites W1485490040 @default.
• W2050582064 cites W1569539217 @default.
• W2050582064 cites W1674727977 @default.
• W2050582064 cites W1681535119 @default.
• W2050582064 cites W1758831574 @default.
• W2050582064 cites W1989214046 @default.
• W2050582064 cites W2008048358 @default.
• W2050582064 cites W2013761846 @default.
• W2050582064 cites W2015647584 @default.
• W2050582064 cites W2022446410 @default.
• W2050582064 cites W2032920422 @default.
• W2050582064 cites W2034867537 @default.
• W2050582064 cites W2058664007 @default.
• W2050582064 cites W2064093411 @default.
• W2050582064 cites W2069682857 @default.
• W2050582064 cites W2089713944 @default.
• W2050582064 cites W2089906160 @default.
• W2050582064 cites W2093226802 @default.
• W2050582064 cites W2093948103 @default.
• W2050582064 doi "https://doi.org/10.1016/0065-2571(90)90027-y" @default.
• W2050582064 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2206023" @default.
• W2050582064 hasPublicationYear "1990" @default.
• W2050582064 type Work @default.
• W2050582064 sameAs 2050582064 @default.
• W2050582064 citedByCount "9" @default.
• W2050582064 countsByYear W20505820642015 @default.
• W2050582064 crossrefType "journal-article" @default.
• W2050582064 hasAuthorship W2050582064A5026359029 @default.
• W2050582064 hasConcept C153911025 @default.
• W2050582064 hasConcept C159654299 @default.
• W2050582064 hasConcept C170493617 @default.
• W2050582064 hasConcept C181199279 @default.
• W2050582064 hasConcept C182220744 @default.
• W2050582064 hasConcept C185592680 @default.
• W2050582064 hasConcept C195616568 @default.
• W2050582064 hasConcept C203014093 @default.
• W2050582064 hasConcept C2779726688 @default.
• W2050582064 hasConcept C2781406822 @default.
• W2050582064 hasConcept C49802076 @default.
• W2050582064 hasConcept C55493867 @default.
• W2050582064 hasConcept C86803240 @default.
• W2050582064 hasConcept C95444343 @default.
• W2050582064 hasConceptScore W2050582064C153911025 @default.
• W2050582064 hasConceptScore W2050582064C159654299 @default.
• W2050582064 hasConceptScore W2050582064C170493617 @default.
• W2050582064 hasConceptScore W2050582064C181199279 @default.
• W2050582064 hasConceptScore W2050582064C182220744 @default.
• W2050582064 hasConceptScore W2050582064C185592680 @default.
• W2050582064 hasConceptScore W2050582064C195616568 @default.
• W2050582064 hasConceptScore W2050582064C203014093 @default.
• W2050582064 hasConceptScore W2050582064C2779726688 @default.
• W2050582064 hasConceptScore W2050582064C2781406822 @default.
• W2050582064 hasConceptScore W2050582064C49802076 @default.
• W2050582064 hasConceptScore W2050582064C55493867 @default.
• W2050582064 hasConceptScore W2050582064C86803240 @default.
• W2050582064 hasConceptScore W2050582064C95444343 @default.
• W2050582064 hasLocation W20505820641 @default.
• W2050582064 hasLocation W20505820642 @default.
• W2050582064 hasOpenAccess W2050582064 @default.
• W2050582064 hasPrimaryLocation W20505820641 @default.
• W2050582064 hasRelatedWork W1751541220 @default.
• W2050582064 hasRelatedWork W1751846561 @default.
• W2050582064 hasRelatedWork W1981841725 @default.
• W2050582064 hasRelatedWork W2033107127 @default.
• W2050582064 hasRelatedWork W2072040223 @default.
• W2050582064 hasRelatedWork W2077331559 @default.
• W2050582064 hasRelatedWork W2118196531 @default.
• W2050582064 hasRelatedWork W2416302103 @default.
• W2050582064 hasRelatedWork W2972751642 @default.
• W2050582064 hasRelatedWork W624447295 @default.
• W2050582064 hasVolume "30" @default.
• W2050582064 isParatext "false" @default.
• W2050582064 isRetracted "false" @default.
• W2050582064 magId "2050582064" @default.
• W2050582064 workType "article" @default.