FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050585055> ?p ?o ?g. }

• W2050585055 endingPage "3803" @default.
• W2050585055 startingPage "3798" @default.
• W2050585055 abstract "Aeruginosins are a family of naturally occurring oligopeptides that share a common bicyclic amino acid core structure. Many compounds in the family are inhibitors of serine proteases, such as thrombin and trypsin. Thrombin is an important enzyme in the blood coagulation cascade, and is a promising target for anticoagulant drug development. In order to understand the structure–activity relationship (SAR) and to find selective thrombin inhibitors, we synthesized a series of aeruginosin 298-A analogs, in which the P2 bicyclic amino acid was replaced by a l-proline residue. The structure optimization was focused on modification of the P1 position. In choosing the P1 group, an effort was made to avoid using the highly basic guanidine groups present in nearly all naturally occurring aeruginosins. The synthesis and enzyme assays of these aeruginosin analogs against thrombin and trypsin are reported. We found that several compounds with neutral P1 groups exhibit excellent selectivity over trypsin and good potency against thrombin. The SAR data of the P1 groups obtained here can be used in preparing other thrombin inhibitors with better selectivity against trypsin." @default.
• W2050585055 created "2016-06-24" @default.
• W2050585055 creator A5028307652 @default.
• W2050585055 creator A5029272162 @default.
• W2050585055 creator A5064535707 @default.
• W2050585055 date "2009-07-01" @default.
• W2050585055 modified "2023-09-24" @default.
• W2050585055 title "Preparation of l-proline based aeruginosin 298-A analogs: Optimization of the P1-moiety" @default.
• W2050585055 cites W1546639563 @default.
• W2050585055 cites W1968797532 @default.
• W2050585055 cites W1971540757 @default.
• W2050585055 cites W1973227757 @default.
• W2050585055 cites W1973598154 @default.
• W2050585055 cites W1973755249 @default.
• W2050585055 cites W1979904607 @default.
• W2050585055 cites W1987621743 @default.
• W2050585055 cites W1990752820 @default.
• W2050585055 cites W1998208586 @default.
• W2050585055 cites W2010406656 @default.
• W2050585055 cites W2016741416 @default.
• W2050585055 cites W2018115856 @default.
• W2050585055 cites W2021098106 @default.
• W2050585055 cites W2034111633 @default.
• W2050585055 cites W2035725580 @default.
• W2050585055 cites W2037709337 @default.
• W2050585055 cites W2043673855 @default.
• W2050585055 cites W2047771492 @default.
• W2050585055 cites W2055844415 @default.
• W2050585055 cites W2065957284 @default.
• W2050585055 cites W2068648667 @default.
• W2050585055 cites W2070929861 @default.
• W2050585055 cites W2071323441 @default.
• W2050585055 cites W2075568120 @default.
• W2050585055 cites W2076272340 @default.
• W2050585055 cites W2080398416 @default.
• W2050585055 cites W2081701896 @default.
• W2050585055 cites W2086713250 @default.
• W2050585055 cites W2087028668 @default.
• W2050585055 cites W2121747898 @default.
• W2050585055 cites W2122520819 @default.
• W2050585055 cites W2146321546 @default.
• W2050585055 cites W2150360454 @default.
• W2050585055 cites W2152596956 @default.
• W2050585055 cites W2176067577 @default.
• W2050585055 cites W2312668521 @default.
• W2050585055 cites W2334940563 @default.
• W2050585055 cites W2915561650 @default.
• W2050585055 cites W2949767353 @default.
• W2050585055 cites W2950539162 @default.
• W2050585055 cites W4242855393 @default.
• W2050585055 cites W4249262763 @default.
• W2050585055 cites W4362235782 @default.
• W2050585055 cites W2152013970 @default.
• W2050585055 doi "https://doi.org/10.1016/j.bmcl.2009.04.056" @default.
• W2050585055 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19447619" @default.
• W2050585055 hasPublicationYear "2009" @default.
• W2050585055 type Work @default.
• W2050585055 sameAs 2050585055 @default.
• W2050585055 citedByCount "10" @default.
• W2050585055 countsByYear W20505850552013 @default.
• W2050585055 countsByYear W20505850552014 @default.
• W2050585055 countsByYear W20505850552015 @default.
• W2050585055 countsByYear W20505850552017 @default.
• W2050585055 countsByYear W20505850552018 @default.
• W2050585055 countsByYear W20505850552020 @default.
• W2050585055 countsByYear W20505850552022 @default.
• W2050585055 countsByYear W20505850552023 @default.
• W2050585055 crossrefType "journal-article" @default.
• W2050585055 hasAuthorship W2050585055A5028307652 @default.
• W2050585055 hasAuthorship W2050585055A5029272162 @default.
• W2050585055 hasAuthorship W2050585055A5064535707 @default.
• W2050585055 hasConcept C118792377 @default.
• W2050585055 hasConcept C161790260 @default.
• W2050585055 hasConcept C181199279 @default.
• W2050585055 hasConcept C182220744 @default.
• W2050585055 hasConcept C185592680 @default.
• W2050585055 hasConcept C203014093 @default.
• W2050585055 hasConcept C21951064 @default.
• W2050585055 hasConcept C24961977 @default.
• W2050585055 hasConcept C2776414213 @default.
• W2050585055 hasConcept C2776568683 @default.
• W2050585055 hasConcept C2776714187 @default.
• W2050585055 hasConcept C2776980637 @default.
• W2050585055 hasConcept C2777292125 @default.
• W2050585055 hasConcept C2777807008 @default.
• W2050585055 hasConcept C2780340462 @default.
• W2050585055 hasConcept C515207424 @default.
• W2050585055 hasConcept C55493867 @default.
• W2050585055 hasConcept C57002609 @default.
• W2050585055 hasConcept C71240020 @default.
• W2050585055 hasConcept C86803240 @default.
• W2050585055 hasConcept C89560881 @default.
• W2050585055 hasConceptScore W2050585055C118792377 @default.
• W2050585055 hasConceptScore W2050585055C161790260 @default.
• W2050585055 hasConceptScore W2050585055C181199279 @default.
• W2050585055 hasConceptScore W2050585055C182220744 @default.
• W2050585055 hasConceptScore W2050585055C185592680 @default.
• W2050585055 hasConceptScore W2050585055C203014093 @default.

• next