FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050586795> ?p ?o ?g. }

• W2050586795 endingPage "57" @default.
• W2050586795 startingPage "52" @default.
• W2050586795 abstract "Background: In sinusitis bronchoconstriction is supposed to originate from pharyngobronchial reflexes triggered by seeding of the inflammatory process into the pharynx. Objective: Our aim was to evaluate whether in sinusitis bronchial and extrathoracic airway (EA) dysfunction correlate with morphologic abnormalities of the pharyngeal mucosa. Methods: We performed histamine inhalation challenge, nasal lavage, and nasopharyngeal biopsies in 24 nonasthmatic patients with exacerbation of chronic sinusitis. The histamine PC20 was the threshold of bronchial responsiveness, and that causing 25% fall in maximal midinspiratory flow was the threshold of EA responsiveness (PC25MIF50). Thresholds of 8 mg/ml or less were assumed to indicate bronchial hyperresponsiveness (BHR) or EA hyperresponsiveness (EAHR). PC20 and PC25MIF50 values were related to clinical data, nasal lavage fluid eosinophils, pharyngeal epithelium and basement membrane thickness, and density of submucosal vessels and nervous fibers. Results: The PC20 was closely related to PC25MIF50 (p = 0.0004). Ten patients had EAHR, 9 had combined EAHR and BHR, and 5 had neither EAHR nor BHR. EAHR was strongly associated with epithelial thinning, and BHR with long-standing sinusitis, a lower PC25MIF50, increased submucosal nerve density and increased nasal lavage fluid eosinophils. Conclusions: Our findings suggest that in nonasthmatic patients with sinusitis, pharyngeal damage may contribute to airway dysfunction by favoring the access of irritants to submucosal nerve endings, with activation of constrictive reflexes to the EA. Proliferation of sensory neurons, consequent to long-lasting pharyngeal inflammation, may cause more severe EA narrowing and activate pharyngobronchial reflexes. (J Allergy Clin Immunol 1997;100:52-7.)" @default.
• W2050586795 created "2016-06-24" @default.
• W2050586795 creator A5002953080 @default.
• W2050586795 creator A5052505482 @default.
• W2050586795 creator A5056070609 @default.
• W2050586795 creator A5057000613 @default.
• W2050586795 creator A5060292739 @default.
• W2050586795 creator A5069606284 @default.
• W2050586795 creator A5080326198 @default.
• W2050586795 creator A5083691447 @default.
• W2050586795 date "1997-07-01" @default.
• W2050586795 modified "2023-09-23" @default.
• W2050586795 title "Damage of the pharyngeal mucosa and hyperresponsiveness of airway in sinusitis☆☆☆★★★" @default.
• W2050586795 cites W1507481562 @default.
• W2050586795 cites W1657740120 @default.
• W2050586795 cites W1679794873 @default.
• W2050586795 cites W1881853677 @default.
• W2050586795 cites W1968090234 @default.
• W2050586795 cites W1974033149 @default.
• W2050586795 cites W1994450734 @default.
• W2050586795 cites W2003084114 @default.
• W2050586795 cites W2013764600 @default.
• W2050586795 cites W2024842436 @default.
• W2050586795 cites W2027242741 @default.
• W2050586795 cites W2031880739 @default.
• W2050586795 cites W2046951514 @default.
• W2050586795 cites W2061265218 @default.
• W2050586795 cites W2080119725 @default.
• W2050586795 cites W2080502516 @default.
• W2050586795 cites W2080764956 @default.
• W2050586795 cites W2087354425 @default.
• W2050586795 cites W2114518763 @default.
• W2050586795 cites W2116315384 @default.
• W2050586795 cites W2118646506 @default.
• W2050586795 cites W2137102246 @default.
• W2050586795 cites W2312658633 @default.
• W2050586795 cites W2338760211 @default.
• W2050586795 cites W2411143019 @default.
• W2050586795 cites W2412583831 @default.
• W2050586795 cites W2416423732 @default.
• W2050586795 cites W2471635718 @default.
• W2050586795 cites W3204766384 @default.
• W2050586795 doi "https://doi.org/10.1016/s0091-6749(97)70194-5" @default.
• W2050586795 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9257787" @default.
• W2050586795 hasPublicationYear "1997" @default.
• W2050586795 type Work @default.
• W2050586795 sameAs 2050586795 @default.
• W2050586795 citedByCount "51" @default.
• W2050586795 countsByYear W20505867952012 @default.
• W2050586795 countsByYear W20505867952013 @default.
• W2050586795 countsByYear W20505867952014 @default.
• W2050586795 countsByYear W20505867952015 @default.
• W2050586795 countsByYear W20505867952018 @default.
• W2050586795 countsByYear W20505867952019 @default.
• W2050586795 countsByYear W20505867952022 @default.
• W2050586795 crossrefType "journal-article" @default.
• W2050586795 hasAuthorship W2050586795A5002953080 @default.
• W2050586795 hasAuthorship W2050586795A5052505482 @default.
• W2050586795 hasAuthorship W2050586795A5056070609 @default.
• W2050586795 hasAuthorship W2050586795A5057000613 @default.
• W2050586795 hasAuthorship W2050586795A5060292739 @default.
• W2050586795 hasAuthorship W2050586795A5069606284 @default.
• W2050586795 hasAuthorship W2050586795A5080326198 @default.
• W2050586795 hasAuthorship W2050586795A5083691447 @default.
• W2050586795 hasConcept C105702510 @default.
• W2050586795 hasConcept C105922876 @default.
• W2050586795 hasConcept C126322002 @default.
• W2050586795 hasConcept C142724271 @default.
• W2050586795 hasConcept C203014093 @default.
• W2050586795 hasConcept C2776178081 @default.
• W2050586795 hasConcept C2776238763 @default.
• W2050586795 hasConcept C2776752453 @default.
• W2050586795 hasConcept C2777714996 @default.
• W2050586795 hasConcept C2777768476 @default.
• W2050586795 hasConcept C2780769369 @default.
• W2050586795 hasConcept C40956017 @default.
• W2050586795 hasConcept C42219234 @default.
• W2050586795 hasConcept C59377437 @default.
• W2050586795 hasConcept C71924100 @default.
• W2050586795 hasConcept C83974742 @default.
• W2050586795 hasConceptScore W2050586795C105702510 @default.
• W2050586795 hasConceptScore W2050586795C105922876 @default.
• W2050586795 hasConceptScore W2050586795C126322002 @default.
• W2050586795 hasConceptScore W2050586795C142724271 @default.
• W2050586795 hasConceptScore W2050586795C203014093 @default.
• W2050586795 hasConceptScore W2050586795C2776178081 @default.
• W2050586795 hasConceptScore W2050586795C2776238763 @default.
• W2050586795 hasConceptScore W2050586795C2776752453 @default.
• W2050586795 hasConceptScore W2050586795C2777714996 @default.
• W2050586795 hasConceptScore W2050586795C2777768476 @default.
• W2050586795 hasConceptScore W2050586795C2780769369 @default.
• W2050586795 hasConceptScore W2050586795C40956017 @default.
• W2050586795 hasConceptScore W2050586795C42219234 @default.
• W2050586795 hasConceptScore W2050586795C59377437 @default.
• W2050586795 hasConceptScore W2050586795C71924100 @default.
• W2050586795 hasConceptScore W2050586795C83974742 @default.
• W2050586795 hasIssue "1" @default.
• W2050586795 hasLocation W20505867951 @default.

• next