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- W2050591785 abstract "In their letter to the Editor, Dr. M.I. Harma and colleagues claim that there are a number of problems associated with the d-ROMs test and related tests, such as the FORT. For example, the letter claims that a problem with the d-ROMs test is that it fails to show a linear correlation with H2O2, suggesting that the d-ROMs test is a poor measure of oxidative stress. Whether or not this problem truly exists with the d-ROMs test is unclear, because the article cited by Harma and colleagues fails to show any data on the analyses they conducted between the d-ROMs test and H2O2 [ [1] Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem. 2005; 38: 1103-1111 Crossref PubMed Scopus (2173) Google Scholar ]. In any event, we do not think this problem exists with the FORT. In fact, we would like to report that our own in vitro studies have found a strong linear correlation between the FORT and H2O2 (Fig. 1). In an additional in vitro study, we found a strong linear correlation between the FORT and lipid hydroperoxides (R2 = .91). These in vitro studies suggest the FORT may be a useful marker of oxidative stress. The FORT test—A novel oxidative stress marker or a well-known measure of ceruloplasmin oxidase activity?AtherosclerosisVol. 187Issue 2PreviewWe read with interest the article by Abramson et al. suggesting that oxidative stress, as measured by the free oxygen radical test (FORT), may be a determinant of CRP levels and promote pro-atherosclerotic inflammatory processes at the earliest stages of CHD development [1]. In this study, the correlation between FORT results and acute phase reactant hsCRP was investigated and a highly significant positive correlation was found. Full-Text PDF" @default.
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- W2050591785 date "2006-08-01" @default.
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- W2050591785 title "The FORT test: Reply to Dr Harma and colleagues" @default.
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- W2050591785 doi "https://doi.org/10.1016/j.atherosclerosis.2006.02.029" @default.
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