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- W2050598710 abstract "A novel series of uniquely functionalized 3-aminocyclobut-2-en-1-ones has been prepared by facile condensation of a variety of cyclobuta-1,3-diones with a phenylalanine-derived primary amine. These systems subsequently lend themselves to substitution at C-2 by reaction with a variety of electrophilic reagents including N-halosuccinimides, sulfenyl chlorides, and Eschenmoser's salt. Compounds from this novel series are potent antagonists of VLA-4." @default.
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- W2050598710 date "2003-06-01" @default.
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- W2050598710 title "Efficient Synthesis of 3-Aminocyclobut-2-en-1-ones: Squaramide Surrogates as Potent VLA-4 Antagonists" @default.
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- W2050598710 doi "https://doi.org/10.1021/ol034701n" @default.
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