FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050598907> ?p ?o ?g. }

• W2050598907 endingPage "5483" @default.
• W2050598907 startingPage "5473" @default.
• W2050598907 abstract "Breast cancer is the most common cancer in women worldwide. Aberrant lipid metabolism is an established hallmark of cancer cells. The recently isolated lysophosphatidylcholine acyltransferase 1 (LPCAT1), the most important enzyme in membrane biogenesis, has been currently implicated in cancer development and progression. The published literature lacks comprehensive reports on LPCAT1 expression in breast cancer and its impact on patients’ outcome. We evaluated the immunohistochemical expression of LPCAT1 in 80 primary breast carcinomas, 24 metastatic lymph nodes, and 30 non-neoplastic breast tissue specimens and statistically analyzed the association between LPCAT1 expression and clinicopathological variables and patients’ outcome. LPCAT1 protein was significantly upregulated in primary breast carcinoma and showed a significant ascending pattern being the lowest in normal breast tissues, relatively increased in fibrocystic disease, and the highest in primary carcinoma. LPCAT1 expression was significantly higher at tumor’s advancing edge and correlated positively with tumor’s grade and TNM stage. Compared to primary tumor, LPCAT1 expression was significantly lower in ductal carcinoma in situ and significantly higher in metastatic lymph nodes. LPCAT1 overexpression was significantly associated with increased proliferative activity, negative estrogen receptor (ER) and progesterone receptor (PR) status, positive human epidermal growth factor receptor 2 (HER2) status, as well as triple-negative and HER2 disease molecular subtypes. Multivariate analysis showed that advanced stage, high grade, and LPCAT1 overexpression were independent predictors of early tumor recurrence. We conclude that LPCAT1 is implicated in breast cancer pathogenesis, evolution, and progression and appears to play a potentially crucial role as a determinant of local invasiveness and metastasis. LPCAT1 is an independent predictor of early tumor recurrence of breast carcinoma and represents a novel prognostic biomarker that reflects underlying biological alterations and thus constitutes a potentially promising target for new therapeutic strategies." @default.
• W2050598907 created "2016-06-24" @default.
• W2050598907 creator A5032077019 @default.
• W2050598907 creator A5085215087 @default.
• W2050598907 date "2015-02-16" @default.
• W2050598907 modified "2023-09-26" @default.
• W2050598907 title "Lysophosphatidylcholine acyltransferase 1 (LPCAT1) upregulation in breast carcinoma contributes to tumor progression and predicts early tumor recurrence" @default.
• W2050598907 cites W1590614915 @default.
• W2050598907 cites W1955128624 @default.
• W2050598907 cites W1964641616 @default.
• W2050598907 cites W1965427258 @default.
• W2050598907 cites W1967968986 @default.
• W2050598907 cites W1974083452 @default.
• W2050598907 cites W1977911448 @default.
• W2050598907 cites W1982268890 @default.
• W2050598907 cites W1994049274 @default.
• W2050598907 cites W2005970787 @default.
• W2050598907 cites W2010871781 @default.
• W2050598907 cites W2016075273 @default.
• W2050598907 cites W2020712625 @default.
• W2050598907 cites W2022240786 @default.
• W2050598907 cites W2023518167 @default.
• W2050598907 cites W2034084750 @default.
• W2050598907 cites W2042623389 @default.
• W2050598907 cites W2042638516 @default.
• W2050598907 cites W2044182294 @default.
• W2050598907 cites W2044702943 @default.
• W2050598907 cites W2048540822 @default.
• W2050598907 cites W2057214988 @default.
• W2050598907 cites W2060416156 @default.
• W2050598907 cites W2062096523 @default.
• W2050598907 cites W2068252345 @default.
• W2050598907 cites W2071389910 @default.
• W2050598907 cites W2073618702 @default.
• W2050598907 cites W2075601790 @default.
• W2050598907 cites W2077328356 @default.
• W2050598907 cites W2095777272 @default.
• W2050598907 cites W2106787323 @default.
• W2050598907 cites W2115910689 @default.
• W2050598907 cites W2116308534 @default.
• W2050598907 cites W2119851259 @default.
• W2050598907 cites W2128680328 @default.
• W2050598907 cites W2129175864 @default.
• W2050598907 cites W2130900820 @default.
• W2050598907 cites W2137853125 @default.
• W2050598907 cites W2150134401 @default.
• W2050598907 cites W2153178365 @default.
• W2050598907 cites W2157840751 @default.
• W2050598907 cites W2158138282 @default.
• W2050598907 cites W2168814200 @default.
• W2050598907 cites W2214029008 @default.
• W2050598907 cites W2312693831 @default.
• W2050598907 cites W2323983892 @default.
• W2050598907 doi "https://doi.org/10.1007/s13277-015-3214-8" @default.
• W2050598907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25683484" @default.
• W2050598907 hasPublicationYear "2015" @default.
• W2050598907 type Work @default.
• W2050598907 sameAs 2050598907 @default.
• W2050598907 citedByCount "54" @default.
• W2050598907 countsByYear W20505989072015 @default.
• W2050598907 countsByYear W20505989072016 @default.
• W2050598907 countsByYear W20505989072017 @default.
• W2050598907 countsByYear W20505989072018 @default.
• W2050598907 countsByYear W20505989072019 @default.
• W2050598907 countsByYear W20505989072020 @default.
• W2050598907 countsByYear W20505989072021 @default.
• W2050598907 countsByYear W20505989072022 @default.
• W2050598907 countsByYear W20505989072023 @default.
• W2050598907 crossrefType "journal-article" @default.
• W2050598907 hasAuthorship W2050598907A5032077019 @default.
• W2050598907 hasAuthorship W2050598907A5085215087 @default.
• W2050598907 hasConcept C121608353 @default.
• W2050598907 hasConcept C126322002 @default.
• W2050598907 hasConcept C143998085 @default.
• W2050598907 hasConcept C2777546739 @default.
• W2050598907 hasConcept C2779013556 @default.
• W2050598907 hasConcept C2779256057 @default.
• W2050598907 hasConcept C2780283643 @default.
• W2050598907 hasConcept C502942594 @default.
• W2050598907 hasConcept C530470458 @default.
• W2050598907 hasConcept C71924100 @default.
• W2050598907 hasConcept C84606932 @default.
• W2050598907 hasConcept C86803240 @default.
• W2050598907 hasConceptScore W2050598907C121608353 @default.
• W2050598907 hasConceptScore W2050598907C126322002 @default.
• W2050598907 hasConceptScore W2050598907C143998085 @default.
• W2050598907 hasConceptScore W2050598907C2777546739 @default.
• W2050598907 hasConceptScore W2050598907C2779013556 @default.
• W2050598907 hasConceptScore W2050598907C2779256057 @default.
• W2050598907 hasConceptScore W2050598907C2780283643 @default.
• W2050598907 hasConceptScore W2050598907C502942594 @default.
• W2050598907 hasConceptScore W2050598907C530470458 @default.
• W2050598907 hasConceptScore W2050598907C71924100 @default.
• W2050598907 hasConceptScore W2050598907C84606932 @default.
• W2050598907 hasConceptScore W2050598907C86803240 @default.
• W2050598907 hasIssue "7" @default.
• W2050598907 hasLocation W20505989071 @default.
• W2050598907 hasLocation W20505989072 @default.

• next