Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050643070> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2050643070 endingPage "27" @default.
- W2050643070 startingPage "22" @default.
- W2050643070 abstract "Conjugated catecholamines in the circulation and in peripheral tissues were measured together with free catecholamines in an attempt to investigate whether there are in vivo correlates to a possible biological role of dopamine sulfate suggested by an in vitro finding of direct conversion of dopamine sulfate to free norepinephrine by dopamine β-hydroxylase.Following the strong sympathoadrenergic stimulus of surgical stress accompanied by an increase in blood pressure and heart rate, conjugated dopamine showed a twofold rise in arterial plasma (p < 0.005) together with increases of all free catecholamines (0.005 < p < 0.02), while conjugates of noreprinephrine and epinephrine decreased in the circulation (0.01 < p < 0.05). Measurements of arteriovenous differences have shown that release of conjugated dopamine occurred from the adrenal gland during operation along with free catecholamines. However, the venous outflow of conjugated dopamine from liver and kidney did not exceed its arterial influx. Conjugated dopamine, in contrast with other conjugates, is present in adrenals, liver, small intestine, and kidney with higher concentrations than free dopamine in the adrenals (p < 0.01). After ultracentrifugation, the chromaffin granule fraction of the adrenal medulla (site of dopamine β-hydroxylase) contains large amounts of conjugated dopamine (apparently sulfate) suggesting a selective accumulation of dopamine sulfate as a readily available free norepinephrine precursor during stress.These findings establish major in vivo differences between peripheral conjugated dopamine and conjugates of norepinephrine and epinephrine. They suggest that there may be biological roles for conjugated dopamine beyond that of a dopamine metabolite." @default.
- W2050643070 created "2016-06-24" @default.
- W2050643070 creator A5022987191 @default.
- W2050643070 creator A5052836637 @default.
- W2050643070 creator A5078778552 @default.
- W2050643070 creator A5085649839 @default.
- W2050643070 date "1980-01-01" @default.
- W2050643070 modified "2023-10-15" @default.
- W2050643070 title "Conjugated dopamine: peripheral origin, distribution, and response to acute stress in the dog" @default.
- W2050643070 cites W2049780980 @default.
- W2050643070 doi "https://doi.org/10.1139/y80-005" @default.
- W2050643070 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7378904" @default.
- W2050643070 hasPublicationYear "1980" @default.
- W2050643070 type Work @default.
- W2050643070 sameAs 2050643070 @default.
- W2050643070 citedByCount "39" @default.
- W2050643070 countsByYear W20506430702013 @default.
- W2050643070 countsByYear W20506430702014 @default.
- W2050643070 countsByYear W20506430702020 @default.
- W2050643070 crossrefType "journal-article" @default.
- W2050643070 hasAuthorship W2050643070A5022987191 @default.
- W2050643070 hasAuthorship W2050643070A5052836637 @default.
- W2050643070 hasAuthorship W2050643070A5078778552 @default.
- W2050643070 hasAuthorship W2050643070A5085649839 @default.
- W2050643070 hasConcept C126322002 @default.
- W2050643070 hasConcept C134018914 @default.
- W2050643070 hasConcept C150903083 @default.
- W2050643070 hasConcept C185592680 @default.
- W2050643070 hasConcept C207001950 @default.
- W2050643070 hasConcept C2775859304 @default.
- W2050643070 hasConcept C2775894120 @default.
- W2050643070 hasConcept C2777597313 @default.
- W2050643070 hasConcept C2778514916 @default.
- W2050643070 hasConcept C513476851 @default.
- W2050643070 hasConcept C71924100 @default.
- W2050643070 hasConcept C86803240 @default.
- W2050643070 hasConceptScore W2050643070C126322002 @default.
- W2050643070 hasConceptScore W2050643070C134018914 @default.
- W2050643070 hasConceptScore W2050643070C150903083 @default.
- W2050643070 hasConceptScore W2050643070C185592680 @default.
- W2050643070 hasConceptScore W2050643070C207001950 @default.
- W2050643070 hasConceptScore W2050643070C2775859304 @default.
- W2050643070 hasConceptScore W2050643070C2775894120 @default.
- W2050643070 hasConceptScore W2050643070C2777597313 @default.
- W2050643070 hasConceptScore W2050643070C2778514916 @default.
- W2050643070 hasConceptScore W2050643070C513476851 @default.
- W2050643070 hasConceptScore W2050643070C71924100 @default.
- W2050643070 hasConceptScore W2050643070C86803240 @default.
- W2050643070 hasIssue "1" @default.
- W2050643070 hasLocation W20506430701 @default.
- W2050643070 hasLocation W20506430702 @default.
- W2050643070 hasOpenAccess W2050643070 @default.
- W2050643070 hasPrimaryLocation W20506430701 @default.
- W2050643070 hasRelatedWork W1493204443 @default.
- W2050643070 hasRelatedWork W1980016226 @default.
- W2050643070 hasRelatedWork W2001073390 @default.
- W2050643070 hasRelatedWork W2012887404 @default.
- W2050643070 hasRelatedWork W2017592125 @default.
- W2050643070 hasRelatedWork W2023322145 @default.
- W2050643070 hasRelatedWork W2031989160 @default.
- W2050643070 hasRelatedWork W2993939856 @default.
- W2050643070 hasRelatedWork W3031624381 @default.
- W2050643070 hasRelatedWork W3098168770 @default.
- W2050643070 hasVolume "58" @default.
- W2050643070 isParatext "false" @default.
- W2050643070 isRetracted "false" @default.
- W2050643070 magId "2050643070" @default.
- W2050643070 workType "article" @default.