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• W2050652565 abstract "The imidazoline compound RX871024 reduces IL-1beta-induced NO production thereby protecting against IL-1beta-induced beta-cell apoptosis. The aim of this study was to evaluate whether imidazolines RX871024 and efaroxan protect beta-cells against death in the presence of a combination of the cytokines IL-1beta, IFNgamma, and TNFalpha. To address this issue, experiments involving different methods for detection of cell death, different concentrations of the cytokines, and a variety of conditions of preparation and culturing of ob/ob mouse islets and beta-cells have been carried out. Thoroughly performed experiments have not been able to demonstrate a protective effect of RX871024 and efaroxan on beta-cell death induced by the combination of cytokines. However, the inhibitory effect of RX871024 on NO production in ob/ob mouse islets and beta-cells was still observed in the presence of all three cytokines and correlated with the decrease in p38 MAPK phosphorylation. Conversely, efaroxan did not affect cytokine-induced NO production. Our data indicate that a combination of pro-inflammatory cytokines IL-1beta, IFNgamma, and TNFalpha, conditions modelling those that take place in type 1 diabetes, induces pancreatic beta-cell death that does not directly correlate with NO production and cannot be counteracted with imidazoline compounds." @default.
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• W2050652565 date "2006-09-01" @default.
• W2050652565 modified "2023-10-15" @default.
• W2050652565 title "RX871024 reduces NO production but does not protect against pancreatic β-cell death induced by proinflammatory cytokines" @default.
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• W2050652565 doi "https://doi.org/10.1016/j.bbrc.2006.06.197" @default.
• W2050652565 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16870144" @default.
• W2050652565 hasPublicationYear "2006" @default.
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