FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050653642> ?p ?o ?g. }

• W2050653642 endingPage "414" @default.
• W2050653642 startingPage "409" @default.
• W2050653642 abstract "Secondary factor VIII (FVIII) prophylaxis converts severe haemophiliacs (FVIII:C < 1 IU dL−1) to a moderate phenotype (FVIII:C ≥ 1 IU dL−1), however, plasma FVIII:C is a poor predictor of bleeding risk. This study used thromboelastography (TEG) and thrombin generation assay (TGA) to quantify coagulation across a 48 h rFVIII prophylaxis period. 10 severe haemophiliacs with varying clinical bleeding phenotypes received their standard rFVIII prophylaxis dose and blood samples were obtained over 48 h. Measured parameters included FVIII:C, TEG and TGA at each time point. FVIII:C pharmacokinetics (PK) and correlation between global assay parameters was performed. The FVIII:C PK parameters were consistent with previous literature. There was significant correlation between FVIII:C and TEG R-time and aPTT (both P < 0.001). Significant correlations existed between FVIII:C and TGA peak, ETP and velocity parameters (all P < 0.001). At 24 h the TEG parameters were sub-therapeutic despite median FVIII:C of 13.0 IU dL−1. TGA was sensitive to FVIII:C below 1 IU dL−1. Those with the severest bleeding phenotype had the lowest TGA parameters. There was significant correlation between FVIII:C and TEG and TGA. TEG lost sensitivity at 48 h, but not TGA. Prospective studies are needed to determine whether these data can be used to design individualized rFVIII prophylaxis regimens." @default.
• W2050653642 created "2016-06-24" @default.
• W2050653642 creator A5019968417 @default.
• W2050653642 creator A5022906539 @default.
• W2050653642 creator A5025270743 @default.
• W2050653642 creator A5030037733 @default.
• W2050653642 creator A5056147053 @default.
• W2050653642 creator A5070042081 @default.
• W2050653642 creator A5078599915 @default.
• W2050653642 date "2013-03-19" @default.
• W2050653642 modified "2023-10-01" @default.
• W2050653642 title "Monitoring rFVIII prophylaxis dosing using global haemostasis assays" @default.
• W2050653642 cites W1520920065 @default.
• W2050653642 cites W1566919421 @default.
• W2050653642 cites W1586981128 @default.
• W2050653642 cites W1895185717 @default.
• W2050653642 cites W1978184135 @default.
• W2050653642 cites W1978722901 @default.
• W2050653642 cites W1986601719 @default.
• W2050653642 cites W2003820644 @default.
• W2050653642 cites W2026954003 @default.
• W2050653642 cites W2038005163 @default.
• W2050653642 cites W2039597791 @default.
• W2050653642 cites W2040917947 @default.
• W2050653642 cites W2045886098 @default.
• W2050653642 cites W2064216283 @default.
• W2050653642 cites W2066569278 @default.
• W2050653642 cites W2070158670 @default.
• W2050653642 cites W2072493867 @default.
• W2050653642 cites W2075409267 @default.
• W2050653642 cites W2089332582 @default.
• W2050653642 cites W2090371144 @default.
• W2050653642 cites W2090633688 @default.
• W2050653642 cites W2095489676 @default.
• W2050653642 cites W2119768870 @default.
• W2050653642 cites W2127414127 @default.
• W2050653642 cites W2133535613 @default.
• W2050653642 cites W2138914609 @default.
• W2050653642 cites W2145399350 @default.
• W2050653642 cites W4239531824 @default.
• W2050653642 doi "https://doi.org/10.1111/hae.12110" @default.
• W2050653642 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3633647" @default.
• W2050653642 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23510278" @default.
• W2050653642 hasPublicationYear "2013" @default.
• W2050653642 type Work @default.
• W2050653642 sameAs 2050653642 @default.
• W2050653642 citedByCount "32" @default.
• W2050653642 countsByYear W20506536422013 @default.
• W2050653642 countsByYear W20506536422014 @default.
• W2050653642 countsByYear W20506536422016 @default.
• W2050653642 countsByYear W20506536422017 @default.
• W2050653642 countsByYear W20506536422018 @default.
• W2050653642 countsByYear W20506536422019 @default.
• W2050653642 countsByYear W20506536422020 @default.
• W2050653642 countsByYear W20506536422022 @default.
• W2050653642 countsByYear W20506536422023 @default.
• W2050653642 crossrefType "journal-article" @default.
• W2050653642 hasAuthorship W2050653642A5019968417 @default.
• W2050653642 hasAuthorship W2050653642A5022906539 @default.
• W2050653642 hasAuthorship W2050653642A5025270743 @default.
• W2050653642 hasAuthorship W2050653642A5030037733 @default.
• W2050653642 hasAuthorship W2050653642A5056147053 @default.
• W2050653642 hasAuthorship W2050653642A5070042081 @default.
• W2050653642 hasAuthorship W2050653642A5078599915 @default.
• W2050653642 hasBestOaLocation W20506536422 @default.
• W2050653642 hasConcept C112705442 @default.
• W2050653642 hasConcept C126322002 @default.
• W2050653642 hasConcept C2777288759 @default.
• W2050653642 hasConcept C2777292125 @default.
• W2050653642 hasConcept C2777664302 @default.
• W2050653642 hasConcept C2778382381 @default.
• W2050653642 hasConcept C3018972837 @default.
• W2050653642 hasConcept C71924100 @default.
• W2050653642 hasConcept C89560881 @default.
• W2050653642 hasConcept C90924648 @default.
• W2050653642 hasConcept C98274493 @default.
• W2050653642 hasConceptScore W2050653642C112705442 @default.
• W2050653642 hasConceptScore W2050653642C126322002 @default.
• W2050653642 hasConceptScore W2050653642C2777288759 @default.
• W2050653642 hasConceptScore W2050653642C2777292125 @default.
• W2050653642 hasConceptScore W2050653642C2777664302 @default.
• W2050653642 hasConceptScore W2050653642C2778382381 @default.
• W2050653642 hasConceptScore W2050653642C3018972837 @default.
• W2050653642 hasConceptScore W2050653642C71924100 @default.
• W2050653642 hasConceptScore W2050653642C89560881 @default.
• W2050653642 hasConceptScore W2050653642C90924648 @default.
• W2050653642 hasConceptScore W2050653642C98274493 @default.
• W2050653642 hasIssue "3" @default.
• W2050653642 hasLocation W20506536421 @default.
• W2050653642 hasLocation W20506536422 @default.
• W2050653642 hasLocation W20506536423 @default.
• W2050653642 hasLocation W20506536424 @default.
• W2050653642 hasOpenAccess W2050653642 @default.
• W2050653642 hasPrimaryLocation W20506536421 @default.
• W2050653642 hasRelatedWork W1537546222 @default.
• W2050653642 hasRelatedWork W1978184135 @default.
• W2050653642 hasRelatedWork W1991130709 @default.
• W2050653642 hasRelatedWork W2004325424 @default.

• next